Florida may have travel restrictions in place due to COVID-19.

Find out moreOpens in new tab or window

Find 5 Star Hotels in Gainesville, FL from $150

Search over 1 million properties and 550 airlines worldwide

Members save 10% more on select hotels, cars, activities and vacation rentals. Sign up.

Free cancellation on most hotels. Because flexibility matters.

Explore similar 4-star hotels

Many 4-star hotels have the same amenities as 5-star hotels. See all 4-star hotels in Gainesville.

Still don't see what you're looking for?

See all properties in Gainesville.
You can also use these popular filters to refine your search.
Lowest nightly price found within the past 24 hours based on a 1 night stay for 2 adults. Prices and availability subject to change. Additional terms may apply.

Ready to experience the next standard in luxury? We know you are thinking about it. Why not ask for the best of accommodations on your trip to Gainesville? There's no reason to delay a getaway to Gainesville any longer. You'll join the multitudes of vacationers who have made Gainesville so fashionable recently. The accommodations in Gainesville also offer great customer service, averaging 3.9 in our ranking system, so you know you'll be taken care of. Don't wait any longer. Reserve one of our 5-star hotels in Gainesville and indulge in the finer things in life for a while.

Book the Best Gainesville 5-Star Hotels

You can expect high quality from your hotel. Top-notch customer care, granite-tiled bathrooms, and rejuvenating spa offerings are all on offer. Our numerous hotels in the area will ensure you find the perfect space to kick back after a long day. You'll be pleased to note that the hotels in Gainesville offer great customer service, averaging 3.9 in our ranking system, so you know you're in good hands. What kind of amenities will make your stay a wonderful one? A concierge to help you pick out your next adventure? A full-body massage to help your cares fall away? Beautiful furniture, lip-smacking main courses, and even spectacular views...these hotels are one-of-a-kind. Don't want to take our word for it? Then explore the 1,153 reviews various guests have left on Expedia and get to know these places.

Yearning for experiences outside your hotel room? Don't worry. From doing a bit of shopping to embracing the great outdoors, you'll never be bored on this retreat. Whatever you plan to do, the 5-star hotels in Gainesville are the perfect place to rest up after an exciting day.

Make Your Escape

The results are in, and Gainesville 5-star hotels are the place to be when you book your next vacation. Many visitors recommend a trip to this location, so don't wait any longer. Expedia can help you land a great deal on accommodation. It's time to plan your next great escape. Select one of the 5-star hotels in Gainesville today and settle down in luxe surroundings tomorrow.

More trip options

Recent reviews of Gainesville hotels