Title: The Best 5 Star Hotels in Gainesville, FL from $104 | Expedia.com

[Gainesville Travel Guide](https://expedia.com/Gainesville.dx6048189)[Hotels in Gainesville](https://expedia.com/Gainesville-Hotels.d6048189.Travel-Guide-Hotels)[Vacation Rentals in Gainesville](https://expedia.com/Gainesville-Vacation-Rentals.d6048189.Travel-Guide-VacationRentals)[Flights to Gainesville](https://expedia.com/Cheap-Flights-To-Gainesville.d6048189.Travel-Guide-Flights)[Things to do in Gainesville](https://expedia.com/Things-To-Do-In-Gainesville.d6048189.Travel-Guide-Activities)[Car Rentals in Gainesville](https://expedia.com/Car-Rentals-In-Gainesville.d6048189.Car-Rental-Guide)[Gainesville Vacation Packages](https://expedia.com/Gainesville.d6048189.Destination-Travel-Guides)

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## Check availability on Gainesville 5 Star Hotels

Tonight

[Feb 25 - Feb 26](https://www.expedia.com/Hotel-Search?regionId=6048189&startDate=2026-02-25&endDate=2026-02-26&adults=2&star=50&rfrr=TG.LP.CheckPrices.Hotel&openPlayBack=true)

Tomorrow

[Feb 26 - Feb 27](https://www.expedia.com/Hotel-Search?regionId=6048189&startDate=2026-02-26&endDate=2026-02-27&adults=2&star=50&rfrr=TG.LP.CheckPrices.Hotel&openPlayBack=true)

This weekend

[Feb 27 - Mar 1](https://www.expedia.com/Hotel-Search?regionId=6048189&startDate=2026-02-27&endDate=2026-03-01&adults=2&star=50&rfrr=TG.LP.CheckPrices.Hotel&openPlayBack=true)

Next weekend

[Mar 6 - Mar 8](https://www.expedia.com/Hotel-Search?regionId=6048189&startDate=2026-03-06&endDate=2026-03-08&adults=2&star=50&rfrr=TG.LP.CheckPrices.Hotel&openPlayBack=true)

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## Explore similar 4-star hotels

Many 4-star hotels have the same amenities as 5-star hotels. See all 4-star hotels in Gainesville.

![DoubleTree by Hilton Gainesville](https://images.trvl-media.com/lodging/1000000/50000/49700/49617/ff7eaa86_y.jpg?impolicy=resizecrop&rw=402&ra=fit)

### DoubleTree by Hilton Gainesville

3726 Sw 40th Blvd Gainesville FL

$93 nightly

$104 total

Mar 9 - Mar 10

Total with taxes and fees

7.8/10 Good! (1,013 reviews)

[](https://expedia.com/Gainesville-Hotels-DoubleTree-By-Hilton-Gainesville.h49617.Hotel-Information)

![ Grand Two Bedroom Two Bathroom Apartment with Balcony by The Scholar](https://images.trvl-media.com/lodging/113000000/112030000/112021600/112021506/83b7eb2e_y.jpg?impolicy=resizecrop&rw=402&ra=fit)

###  Grand Two Bedroom Two Bathroom Apartment with Balcony by The Scholar

2548 SW 13th St Gainesville FL

$239 nightly

$269 total

Feb 26 - Feb 27

Total with taxes and fees

8.6/10 Excellent! (9 reviews)

[](https://expedia.com/Gainesville-Hotels-The-Scholar.h112021506.Hotel-Information)

![Quiet Convenient and Modern Haven](https://images.trvl-media.com/lodging/91000000/90050000/90049500/90049490/b9ee7a03_y.jpg?impolicy=resizecrop&rw=402&ra=fit)

### Quiet Convenient and Modern Haven

3803 SW 28th Terrace Gainesville FL

[Get rates](https://expedia.com/Hotel-Search?startDate=3%2F11%2F2026&endDate=3%2F12%2F2026&selected=90049490&PinnedHotelID=90049490&HadPinnedHotel=true&regionId=6048189)

[](https://expedia.com/Gainesville-Hotels-Quiet-Convenient-And-Modern-Haven.h90049490.Hotel-Information)

Still don't see what you're looking for?

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Lowest nightly price found within the past 24 hours based on a 1 night stay for 2 adults. Prices and availability subject to change. Additional terms may apply.

## Gainesville and related destinations

- Gainesville
- Lubbock
- Cedar Rapids - Iowa City
- Topeka
- Athens

Home to the Florida Gators, this college town buzzes with energy at The Swamp during football season. Explore the natural springs at Paynes Prairie or stroll through the butterfly-filled exhibits at the Florida Museum of Natural History.

[See all hotels in Gainesville](https://www.expedia.com/Hotel-Search?startDate=2026-03-11&endDate=2026-03-12&adults=2&regionId=6048189)

![Gainesville which includes interior views](https://images.trvl-media.com/place/6048189/2fd588c5-630b-40be-bcf7-489b9c01f85d.jpg?impolicy=fcrop&w=900&h=506&p=1&q=high)

Photo by Visit Gainesville

## Top Gainesville Hotel Reviews

## Find out more about Gainesville

Ready to experience the next standard in luxury? We know you are thinking about it. Why not ask for the best of accommodations on your trip to Gainesville? There's no reason to delay a getaway to Gainesville any longer. You'll join the multitudes of vacationers who have made Gainesville so fashionable recently. The accommodations in Gainesville also offer great customer service, averaging 3.9 in our ranking system, so you know you'll be taken care of. Don't wait any longer. Reserve one of our 5-star hotels in Gainesville and indulge in the finer things in life for a while.

### Book the Best Gainesville 5-Star Hotels

You can expect high quality from your hotel. Top-notch customer care, granite-tiled bathrooms, and rejuvenating spa offerings are all on offer. Our numerous hotels in the area will ensure you find the perfect space to kick back after a long day. You'll be pleased to note that the hotels in Gainesville offer great customer service, averaging 3.9 in our ranking system, so you know you're in good hands. What kind of amenities will make your stay a wonderful one? A concierge to help you pick out your next adventure? A full-body massage to help your cares fall away? Beautiful furniture, lip-smacking main courses, and even spectacular views...these hotels are one-of-a-kind. Don't want to take our word for it? Then explore the 1,153 reviews various guests have left on Expedia and get to know these places. 

Yearning for experiences outside your hotel room? Don't worry. From doing a bit of shopping to embracing the great outdoors, you'll never be bored on this retreat. Whatever you plan to do, the 5-star hotels in Gainesville are the perfect place to rest up after an exciting day.

### Make Your Escape

The results are in, and Gainesville 5-star hotels are the place to be when you book your next vacation. Many visitors recommend a trip to this location, so don't wait any longer. Expedia can help you land a great deal on accommodation. It's time to plan your next great escape. Select one of the 5-star hotels in Gainesville today and settle down in luxe surroundings tomorrow.

## Frequently asked questions

### How much does it cost to stay in a 5-star hotel in Gainesville?

> - Search for the lowest price per night from $104

### What makes a hotel 5 stars in Gainesville?

### Are there any 5-star all-inclusive resorts in Gainesville?

## Explore a world of travel with Expedia

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- [Hippodrome State Theatre ](https://www.expedia.com/Hippodrome-State-Theatre-Gainesville.d6068629.Vacation-Attraction)
- [Matheson History Museum ](https://www.expedia.com/Matheson-Museum-Gainesville.d6187979.Vacation-Attraction)
- [Thomas Center ](https://www.expedia.com/Thomas-Center-Duckpond.d6187991.Vacation-Attraction)
- [University of Florida ](https://www.expedia.com/University-Of-Florida-Gainesville.d6068631.Vacation-Attraction)
- [Ben Hill Griffin Stadium ](https://www.expedia.com/Ben-Hill-Griffin-Stadium-Gainesville.d6068633.Vacation-Attraction)
- [Shands at the University of Florida ](https://www.expedia.com/Shands-At-The-University-Of-Florida-Gainesville.d6187967.Vacation-Attraction)
- [Bivens Arm Nature Park ](https://www.expedia.com/Bivens-Arm-Nature-Park-Gainesville.d6278921.Vacation-Attraction)
- [University of Florida Bat Houses ](https://www.expedia.com/University-Of-Florida-Bat-Houses-Gainesville.d553248621532654132.Vacation-Attraction)
- [Curtis M. Phillips Center ](https://www.expedia.com/Curtis-M-Phillips-Center-Gainesville.d6188013.Vacation-Attraction)
- [Florida Museum of Natural History ](https://www.expedia.com/Florida-Museum-Of-Natural-History-Gainesville.d6068619.Vacation-Attraction)
- [Samuel P. Harn Museum of Art ](https://www.expedia.com/Samuel-P-Harn-Museum-Of-Art-Gainesville.d6068621.Vacation-Attraction)
- [Ironwood Golf Course ](https://www.expedia.com/Ironwood-Golf-Course-Gainesville.d6278915.Vacation-Attraction)
- [Regal Royal Park ](https://www.expedia.com/Regal-Cinemas-Royal-Park-Stadium-16-Gainesville.d553248621563220056.Vacation-Attraction)

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