$268 Cheap Flights from Knoxville (TYS) to Gainesville (GNV)

View $268 flight on Tue, Jul 21, 2026Opens in a new window

Popular airlines from McGhee Tyson Airport (TYS) to Gainesville Regional Airport (GNV)

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Cheap Flights from Knoxville to Gainesville (TYS-GNV)

Prices were available within the past 7 days and start at $268 for one-way flights and $353 for round trip, for the period specified. Prices and availability are subject to change. Additional terms apply.

American Airlines
Tue, Aug 25 - Sat, Aug 29
TYS
Knoxville
GNV
Gainesville
$353 Roundtrip, found 18 hours ago
$353
Roundtrip
found 18 hours ago
Select American Airlines flight, departing Tue, Aug 25 from Knoxville to Gainesville, returning Sat, Aug 29, priced at $353 found 18 hours ago
Delta
Wed, Sep 9 - Sun, Sep 13
TYS
Knoxville
GNV
Gainesville
$357 Roundtrip, found 15 hours ago
$357
Roundtrip
found 15 hours ago
Select Delta flight, departing Wed, Sep 9 from Knoxville to Gainesville, returning Sun, Sep 13, priced at $357 found 15 hours ago
Delta
Fri, Sep 4 - Sun, Sep 6
TYS
Knoxville
GNV
Gainesville
$359 Roundtrip, found 1 day ago
$359
Roundtrip
found 1 day ago
Select Delta flight, departing Fri, Sep 4 from Knoxville to Gainesville, returning Sun, Sep 6, priced at $359 found 1 day ago
American Airlines
Sat, Aug 15 - Sun, Aug 16
TYS
Knoxville
GNV
Gainesville
$363 Roundtrip, found 1 day ago
$363
Roundtrip
found 1 day ago
Select American Airlines flight, departing Sat, Aug 15 from Knoxville to Gainesville, returning Sun, Aug 16, priced at $363 found 1 day ago
Delta
Fri, Sep 11 - Mon, Sep 14
TYS
Knoxville
GNV
Gainesville
$367 Roundtrip, found 13 hours ago
$367
Roundtrip
found 13 hours ago
Select Delta flight, departing Fri, Sep 11 from Knoxville to Gainesville, returning Mon, Sep 14, priced at $367 found 13 hours ago
American Airlines
Tue, Aug 25 - Sat, Aug 29
TYS
Knoxville
GNV
Gainesville
$375 Roundtrip, found 18 hours ago
$375
Roundtrip
found 18 hours ago
Select American Airlines flight, departing Tue, Aug 25 from Knoxville to Gainesville, returning Sat, Aug 29, priced at $375 found 18 hours ago
American Airlines
Tue, Aug 25 - Sat, Aug 29
TYS
Knoxville
GNV
Gainesville
$381 Roundtrip, found 18 hours ago
$381
Roundtrip
found 18 hours ago
Select American Airlines flight, departing Tue, Aug 25 from Knoxville to Gainesville, returning Sat, Aug 29, priced at $381 found 18 hours ago
Delta
Wed, Jul 8 - Sun, Jul 12
TYS
Knoxville
GNV
Gainesville
$387 Roundtrip, found 1 day ago
$387
Roundtrip
found 1 day ago
Select Delta flight, departing Wed, Jul 8 from Knoxville to Gainesville, returning Sun, Jul 12, priced at $387 found 1 day ago
Delta
Wed, Sep 9 - Sun, Sep 13
TYS
Knoxville
GNV
Gainesville
$393 Roundtrip, found 15 hours ago
$393
Roundtrip
found 15 hours ago
Select Delta flight, departing Wed, Sep 9 from Knoxville to Gainesville, returning Sun, Sep 13, priced at $393 found 15 hours ago
Delta
Fri, Sep 4 - Sun, Sep 6
TYS
Knoxville
GNV
Gainesville
$399 Roundtrip, found 1 day ago
$399
Roundtrip
found 1 day ago
Select Delta flight, departing Fri, Sep 4 from Knoxville to Gainesville, returning Sun, Sep 6, priced at $399 found 1 day ago

Frequently asked questions

How much does a flight from Knoxville, TN (TYS-McGhee Tyson) to Gainesville, FL (GNV-Gainesville Regional) cost?
You can find cheap one-way flights from $268 and cheap return flights from $353 Knoxville, TN (TYS-McGhee Tyson) to Gainesville, FL (GNV-Gainesville Regional) with Expedia. One-way flights typically cost between $251 and $729, and return flights often range between $417 and $1514. Flight prices vary based on the month and day of the week you want to travel, as well as the airline and how far in advance you book your ticket. Filter your search on Expedia by "Price (lowest to highest)" to see the cheapest fares first, and use the Price Tracking tool to receive alerts when Knoxville, TN (TYS-McGhee Tyson) to Gainesville, FL (GNV-Gainesville Regional) ticket fares go up or down.*Typical price ranges based on flights available on Expedia in the last year. Prices include multi-airline options.
What is the cheapest month to fly from Knoxville, TN (TYS-McGhee Tyson) to Gainesville, FL (GNV-Gainesville Regional)?
October is the cheapest month to fly from Knoxville, TN (TYS) to Gainesville, FL (GNV), with average round-trip fares around $398. This is about 21% lower than the average price throughout the year, as fall travel often sees reduced demand. Other budget-friendly months include June and August.*Averages based on flights available on Expedia in the last year.
Which airlines fly direct from Knoxville, TN (TYS-McGhee Tyson) to Gainesville, FL (GNV-Gainesville Regional)?
Enter TYS to GNV and your travel dates, then apply the 'Nonstop' filter to see only direct flights.
What is the cheapest airline that flies from Knoxville, TN (TYS-McGhee Tyson) to Gainesville, FL (GNV-Gainesville Regional)?
Delta is one of the cheapest airlines offering nonstop flights from McGhee Tyson (TYS) to Gainesville Regional (GNV), with round-trip tickets starting from around $603. You have a direct option, making your travel plans simpler and more convenient. Use Expedia's search tool to compare the prices and schedules of airlines that fly this route to find the best option for your plans and budget.*Prices based on flights available on Expedia in the last year.
How do I find cheap flights from Knoxville, TN (TYS-McGhee Tyson) to Gainesville, FL (GNV-Gainesville Regional)?
To find a cheap flight from Knoxville, TN (TYS-McGhee Tyson) to Gainesville, FL (GNV-Gainesville Regional), be flexible with your dates. Traveling outside of peak vacation months and booking a mid-week flight can help you save. Early morning and late night flights are often more affordable, too. Expedia allows you to compare flight times, airlines and routes all in one place to find low fares. You can also set up Price Tracking and receive alerts when fares go up or down.
What is the best time to fly from Knoxville, TN (TYS-McGhee Tyson) to Gainesville, FL (GNV-Gainesville Regional)?
The best time to fly from Knoxville to Gainesville is in October or June. Return flights during these months average around $398, making them a great choice. October offers beautiful fall weather, while June is perfect for enjoying the summer warmth.*Prices based on flights available on Expedia in the last year.
What is the earliest flight from Knoxville, TN (TYS-McGhee Tyson) to Gainesville, FL (GNV-Gainesville Regional)?
The earliest flight from Knoxville (TYS) to Gainesville (GNV) usually leaves at around 5:00 AM, operated by American Airlines. This is a seasonal service available in December, and an early departure allows you to maximize your time in Florida. To compare early flights on Expedia, select the "Early Morning" and "Morning" filters in your search.
What are the most popular departure times for flights from Knoxville, TN (TYS-McGhee Tyson) to Gainesville, FL (GNV-Gainesville Regional)?
The most popular departure times for flights from Knoxville (TYS) to Gainesville (GNV) are in the early morning, from 6am to 9am. About 24% of passengers prefer this time window. Many major carriers, including Delta Air Lines and United Airlines, offer flights during this window. This timing is popular because it allows you to arrive in Gainesville with a full day ahead of you.
How long does it take to fly from Knoxville, TN (TYS-McGhee Tyson) to Gainesville, FL (GNV-Gainesville Regional)?
A nonstop flight from TYS to GNV typically takes around 1 hour 30 minutes, covering approximately 434 miles. Connecting flights on this route usually add 2 hours 30 minutes to your travel time. Keep in mind that actual flight times can vary due to wind patterns, weather, and air traffic.
Can you fly business or first class from Knoxville, TN (TYS-McGhee Tyson) to Gainesville, FL (GNV-Gainesville Regional)?
First class seats are offered on the TYS to GNV route with Delta Air Lines and American Airlines.
How do I earn miles on a Knoxville, TN (TYS-McGhee Tyson) to Gainesville, FL (GNV-Gainesville Regional) flight with Expedia?
It's easy to earn miles on a Knoxville, TN (TYS-McGhee Tyson) to Gainesville, FL (GNV-Gainesville Regional) flight when you book with Expedia. Before you confirm your booking, simply select your frequent flyer program and enter your program number. As a member of One Key™, you can also earn OneKeyCash™* on top of your airline miles when you book with Expedia.*Excludes taxes and fees. OneKeyCash is not redeemable for cash and can only be used on Expedia and other participating brands.
What airports do you fly into for Gainesville from McGhee Tyson (TYS)?
From McGhee Tyson (TYS), you can fly into Gainesville Regional (GNV) to reach Gainesville. Some flights may connect through major hubs like George Bush Intercontinental (IAH), O'Hare Intl. (ORD), Washington Dulles Intl. (IAD) before reaching Gainesville. Compare routes and airports on Expedia to find the best flight options for your travel plans.
Is it cheaper to buy a plane ticket from Knoxville, TN (TYS-McGhee Tyson) to Gainesville, FL (GNV-Gainesville Regional) at the last minute?
Typically, booking a last minute flight from Knoxville, TN (TYS-McGhee Tyson) to Gainesville, FL (GNV-Gainesville Regional) will be more expensive than booking in advance. As the departure date approaches, there are usually fewer seats available which can drive up the cost. However, if there's some wiggle room with your travel dates and times, you could bag a cheap last-minute fare.
Is it cheaper to book a Knoxville, TN (TYS-McGhee Tyson) to Gainesville, FL (GNV-Gainesville Regional) flight and hotel package?
Securing a Knoxville, TN (TYS-McGhee Tyson) to Gainesville, FL (GNV-Gainesville Regional) Gainesville Vacation Packages is usually cheaper than booking separately. With Expedia, you can enjoy the ease of organizing your travels all in one place. Select from our extensive range of stays and then add flights, activities and car rentals to your booking. Bundle everything together, and you could save hundreds of dollars.
Can I cancel or change the date of my flight from Knoxville, TN (TYS-McGhee Tyson) to Gainesville, FL (GNV-Gainesville Regional)?
If you booked your Knoxville, TN (TYS-McGhee Tyson) to Gainesville, FL (GNV-Gainesville Regional) flight within the last 24 hours, you may be able to modify or cancel it without any fees. Depending on the airline and the type of ticket you have, additional charges may apply for changes beyond this timeframe. Airline policies and contact information can be found in your itinerary or confirmation email. Or, head to our Customer Service portal if you'd like more information.

Travel information

Origin airport
McGhee Tyson
Destination airport
Gainesville Regional
Airlines serving
American Airlines, Delta
Roundtrip price
$352
Distance
434 mi

Book with confidence

Knoxville to Gainesville Flights

The cheapest times to fly from Knoxville to Gainesville

On average, Thursday can be the cheapest time to fly, according to data from the Airlines Reporting Corporation (ARC), one of the world's biggest databases for global airline sales. The data reveals that you could save up to 16% by flying on a Thursday—the cheapest day to travel on average—instead of a Sunday—the most expensive. Some of the most affordable flights from Knoxville to Gainesville are during the month of August. You can find some of the cheapest flights from Knoxville to Gainesville with Expedia's search tool and vast selection of airlines.

 

The best time to book a flight from Knoxville to Gainesville

Sunday is one of the best days to book for cheap flights from Knoxville to Gainesville: Tickets reserved on a Sunday cost between 6% and 13% less than those reserved on a Friday, according to ARC data. The data also suggests booking early can also lead to cheaper airfares. You could save 24% by buying your tickets for domestic flights at least a month in advance and 10% by booking international flights 2 months in advance.

 

How to find cheap round-trip tickets from Knoxville to Gainesville

Being flexible with your dates and using Expedia's Price Drop Protection and Price Tracking features are some of the best ways of finding a cheap ticket from Knoxville to Gainesville in 2026. You can also book with separate airlines for your outbound and return journeys, from $268 one-way. Expedia also offers Price Drop Protection, so if the cost of your airfare goes down after booking, you'll receive a credit for the difference*. This is available for a small fee, and is free to One Key Gold and Platinum tier members.

 

Expedia's Price Tracking feature means you can stay on top of airfares without manually checking every day. It sends you automated price alerts for cheap Knoxville to Gainesville flights and uses historical data to indicate when the best time to book is. Download Expedia's free app to activate this handy tool in a few easy taps.

 

You could also save big by booking one of Expedia's vacation packages. Bundling together your Knoxville to Gainesville airfare with your accommodations and car rental is often cheaper than booking everything separately. There’s also One Key, Expedia's generous rewards program. Join for free and you could earn One Key cash on most bookings to save on future adventures.

 

*Terms apply.

 

Disclaimer: ARC The statistics are based on average round-trip ticket prices between January and August 2023. The percentages you see are averages.

 

Knoxville to Gainesville Flights

*Flight schedules are subject to change.

*Available to One Key members.

 

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