Top Scott County Hotels: 2026 Best Hotels in Scott County

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Our top choices for Scott County hotels

A Drury Inn & Suites building with a covered entrance, multiple windows, and a parking lot.

1. Drury Inn & Suites Sikeston, MO

Sikeston

Tiffany

$94 nightly

Nov 22 - Nov 23

Total with taxes and fees

A Hampton Inn with a stone facade, outdoor seating area, and a fire pit.

2. Hampton Inn Sikeston

Sikeston

Conner

$101 nightly

Nov 22 - Nov 23

Total with taxes and fees

A hotel with a covered entrance, a sign indicating a restaurant, and a well-lit parking area.

3. Best Western Plus Sikeston I-55

Sikeston

Shelley

$70 nightly

Dec 14 - Dec 15

Total with taxes and fees

A hotel room with two beds, a desk, a chair, a TV, and a large window with curtains.

4. Days Inn and Suites by Wyndham Sikeston

Sikeston

Earl

$66 nightly

Nov 16 - Nov 17

Total with taxes and fees

A hotel room with a TV, microwave, desk, chair, two beds, and a window with curtains.

5. Super 8 by Wyndham Sikeston/Miner Area

Sikeston

Laura

$58 nightly

Nov 22 - Nov 23

Total with taxes and fees

An outdoor seating area with a circular fire pit surrounded by chairs, a covered patio, and a building with large windows in the background.

6. Fairfield Inn & Suites by Marriott Sikeston

Sikeston

Roslyn

$110 nightly

Nov 20 - Nov 21

Total with taxes and fees

A buffet with labeled containers of turkey sausage and cookies.

7. Holiday Inn Express & Suites Sikeston Southwest by IHG

Sikeston

George

$95 nightly

Dec 13 - Dec 14

Total with taxes and fees

A building with a fountain and flower beds in front.

8. The Riverstone Hotel Charleston-Sikeston

Charleston

Kathleen

$66 nightly

Nov 16 - Nov 17

Total with taxes and fees

A hotel room with a large bed, a desk with a computer, a chair, a window with a view, and a wall-mounted TV.

9. Travel Inn & Suites - Sikeston/Miner (i-55 Exit-67)

Sikeston

Craig

$63 nightly

Nov 15 - Nov 16

Total with taxes and fees

A hotel room with a large bed, two bedside lamps, a framed picture of a bridge, and a wooden nightstand with a phone.

10. Super 8 by Wyndham Charleston/Sikeston East MO

Charleston

Judith

$59 nightly

Dec 1 - Dec 2

Total with taxes and fees

A hotel room with a bed, bedside table, desk, chair, telephone, television, and a bathroom with a mirror and sink.

11. Country Yard Inn and Suite

Sikeston

Marianne

$55 nightly

Nov 15 - Nov 16

Total with taxes and fees

A modern building with a flat roof and large windows.

12. Comfort Inn & Suites Sikeston I-55

Sikeston

Fred

$84 nightly

Nov 22 - Nov 23

Total with taxes and fees

13. TownePlace Suites by Marriott Sikeston

Sikeston

Mark

$109 nightly

Nov 22 - Nov 23

Total with taxes and fees

A hotel room with two beds, a nightstand, a lamp, and a window with curtains.

14. Eagle Inn Charleston

Charleston

Jackson

$66 nightly

Nov 15 - Nov 16

Total with taxes and fees

A Drury Plaza Hotel with a modern design, featuring a prominent entrance, multiple floors, and a clear sky.

15. Drury Plaza Hotel Cape Girardeau Conference Center

Cape Girardeau

Melody

$100 nightly

Nov 15 - Nov 16

Total with taxes and fees

A spacious lobby with a curved staircase, large windows, and a seating area with a rug.

16. The Riverview

Cape Girardeau

Irvin

$105 nightly

Nov 15 - Nov 16

Total with taxes and fees

A Dear Tree Inn building with a covered entrance and a clear sky at dusk.

17. Pear Tree Inn Cape Girardeau West

Cape Girardeau

Livia

$72 nightly

Nov 22 - Nov 23

Total with taxes and fees

A hotel room with a large bed, two bedside tables, a desk with a chair, and two lamps.

18. Drury Inn & Suites Cape Girardeau

Cape Girardeau

Mary

$90 nightly

Nov 22 - Nov 23

Total with taxes and fees

A modern hotel with a prominent 'La Quinta' sign, a covered entrance, and a landscaped entrance area.

19. La Quinta Inn & Suites by Wyndham Jackson/Cape Girardeau

Jackson

richard

$80 nightly

Nov 16 - Nov 17

Total with taxes and fees

A spacious lobby with a fireplace, comfortable seating, a staircase, and a large chandelier.

20. Holiday Inn Express Hotel & Suites Cape Girardeau I-55 by IHG

Cape Girardeau

Rebecca

$95 nightly

Dec 13 - Dec 14

Total with taxes and fees

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Compare top hotels in Scott County

Drury Inn & Suites Sikeston, MO 3.0 star property Sikeston View	Hampton Inn Sikeston 2.5 star property Sikeston View	Best Western Plus Sikeston I-55 2.5 star property Sikeston View	Days Inn and Suites by Wyndham Sikeston 2.0 star property Sikeston View	Super 8 by Wyndham Sikeston/Miner Area 2.0 star property Sikeston View
9.6 Exceptional 1,002 reviews	9.0 Wonderful 659 reviews	8.4 Very good 1,000 reviews	7.4 Good 1,001 reviews	7.0 Good 696 reviews
$94 nightly The price is $108 Nov 22 - Nov 23 Total with taxes and fees	$101 nightly The price is $115 Nov 22 - Nov 23 Total with taxes and fees	$70 nightly The price is $80 Dec 14 - Dec 15 Total with taxes and fees	$66 nightly The price is $76 Nov 16 - Nov 17 Total with taxes and fees	$58 nightly The price is $66 Nov 22 - Nov 23 Total with taxes and fees
Yes, Breakfast included Yes, Pool No Spa Yes, Pet friendly Yes, WiFi included Yes, Parking	Yes, Breakfast included Yes, Pool No Spa Yes, Pet friendly Yes, WiFi included Yes, Parking	Yes, Breakfast included Yes, Pool No Spa Yes, Pet friendly No WiFi included Yes, Parking	Yes, Breakfast included No Pool No Spa Yes, Pet friendly Yes, WiFi included Yes, Parking	Yes, Breakfast included No Pool No Spa Yes, Pet friendly Yes, WiFi included Yes, Parking