Wykoff Vacation Rentals

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Our top choices for Wykoff vacation rentals

The Hen House Retreat - A Comfortable Place to Roost

The Hen House Retreat - A Comfortable Place to Roost
Highland
9.8 out of 10, Exceptional, (87)
"Very nice perfect for us, would rent again!"
United States
Mitchell G.
$185 nightly
The price is $199
Dec 30 - Dec 31
Total with taxes and fees
The Hen House Retreat - A Comfortable Place to Roost

Valley Cabin

Valley Cabin
Spring Valley
9.2 out of 10, Wonderful, (7)
"Great property with plenty of outdoor activities. Had fun fishing the stream and exploring the area. Dan is a great host and I will be visiting again."
United States
JAKE I.
$118 nightly
The price is $127
Dec 30 - Dec 31
Total with taxes and fees
Valley Cabin

Apple Blossom Cottage // 2 Miles from Downtown ~ 10 Min to Mayo

Apple Blossom Cottage // 2 Miles from Downtown ~ 10 Min to Mayo
Rochester
9.8 out of 10, Exceptional, (11)
"Very comfortable home away from home"
United States
ROBERT B.
$216 nightly
The price is $248
Jan 4 - Jan 5, 2026
Total with taxes and fees
Apple Blossom Cottage // 2 Miles from Downtown ~ 10 Min to Mayo

1 mile to Mayo 2 step entry Brave Covered By Faith

1 mile to Mayo 2 step entry Brave Covered By Faith
2.0 star property
Parkway
9.8 out of 10, Exceptional, (10)
"This was a PERFECT place to stay if you're going to the Mayo!Jessica is very easy to work with and incredibly responsive!"
United States
Kristin T.
$195 nightly
The price is $224
Jan 6 - Jan 7, 2026
Total with taxes and fees
1 mile to Mayo 2 step entry Brave Covered By Faith

Sage Street Retreat, a quiet and relaxing getaway

Sage Street Retreat, a quiet and relaxing getaway
Lime Springs
9.8 out of 10, Exceptional, (10)
"We really were happy with everything about our stay. Very clean & good beds & quiet neighborhood. Would definitely book again."
United States
Laurie F.
$165 nightly
The price is $173
Dec 30 - Dec 31
Total with taxes and fees
Sage Street Retreat, a quiet and relaxing getaway

Country Cabin In The Heart Of Amish Country In Scenic Valley Near Canton, MN

Country Cabin In The Heart Of Amish Country In Scenic Valley Near Canton, MN
Canton
9.8 out of 10, Exceptional, (180)
"Quiet, relaxing weekend"
United States
Sharon I.
$248 nightly
The price is $266
Dec 30 - Dec 31
Total with taxes and fees
Country Cabin In The Heart Of Amish Country In Scenic Valley Near Canton, MN

Discounted Oasis, 2 Bedroom Lower-Level Duplex 5 Minutes to Mayo Clinic!

Discounted Oasis, 2 Bedroom Lower-Level Duplex 5 Minutes to Mayo Clinic!
Rochester
9.6 out of 10, Exceptional, (25)
"Very clean had everything I needed "
United States
Victoria
$157 nightly
The price is $180
Jan 4 - Jan 5, 2026
Total with taxes and fees
Discounted Oasis, 2 Bedroom Lower-Level Duplex 5 Minutes to Mayo Clinic!

The Berkman

The Berkman
3.0 star property
Folwell
9.6 out of 10, Exceptional, (372)
"Staff was great, as was the room."
United States
Scott
$188 nightly
The price is $216
Dec 30 - Dec 31
Total with taxes and fees
The Berkman

Charming 2-bedroom apartment in delightful Rochester with WiFi, AC

Charming 2-bedroom apartment in delightful Rochester with WiFi, AC
Meadow Park
10.0 out of 10, Exceptional, (1)
"Quiet, clean and in a friendly neighborhood. Staying there took some of the stress out of my Mayo Clinic visits. I always worry about my follow-up visits, but a good quiet place to stay helps me let that go."
United States
Maria L E.
$140 nightly
The price is $201
Dec 30 - Dec 31
Total with taxes and fees
Charming 2-bedroom apartment in delightful Rochester with WiFi, AC

Discounted Charming 2-bedroom house in Rochester

Discounted Charming 2-bedroom house in Rochester
East Side Pioneers
8.6 out of 10, Excellent, (11)
"Great stay for a quick stop in Rochester. Clean, quiet neighborhood."
United States
Jill S.
$168 nightly
The price is $193
Dec 30 - Dec 31
Total with taxes and fees
Discounted Charming 2-bedroom house in Rochester

Broadway Plaza, Trademark Collection by Wyndham

Broadway Plaza, Trademark Collection by Wyndham
3.0 star property
Downtown Rochester
9.2 out of 10, Wonderful, (168)
"Great staff, clean room, spacious kitchen and living room."
United States
silvia
$158 nightly
The price is $181
Jan 9 - Jan 10, 2026
Total with taxes and fees
Broadway Plaza, Trademark Collection by Wyndham

Discounted Oasis! 5 Star-3 Bedroom Showstopping Duplex 4 Minutes to Mayo Clinic!

Discounted Oasis! 5 Star-3 Bedroom Showstopping Duplex 4 Minutes to Mayo Clinic!
East Side Pioneers
9.0 out of 10, Wonderful, (19)
"Great location , close to Mayo clinic as needed. Owner addressed the shower head issue immediately, great communication. "
United States
Barb W.
$191 nightly
The price is $220
Jan 25 - Jan 26, 2026
Total with taxes and fees
Discounted Oasis! 5 Star-3 Bedroom Showstopping Duplex 4 Minutes to Mayo Clinic!

The Little House // Stylish & Cozy ~ 2 mi from Mayo Clinic

The Little House // Stylish & Cozy ~ 2 mi from Mayo Clinic
Slatterly Park
10.0 out of 10, Exceptional, (17)
"We had a wonderful time visiting Minnesota for our first time! We would most definitely stay here again. Had everything we needed and was so great for our dogs to tag along too! Would 100% recommend staying here. "
United States
Hannah C.
$199 nightly
The price is $229
Dec 30 - Dec 31
Total with taxes and fees
The Little House // Stylish & Cozy ~ 2 mi from Mayo Clinic

Close to Mayo & Shops, 1 step entry CoveredByFaith

Close to Mayo & Shops, 1 step entry CoveredByFaith
Rochester
9.8 out of 10, Exceptional, (13)
"Peaceful and relaxing, perfect vacation home. Excellent hosts!!!"
United States
Ellaina M.
$214 nightly
The price is $247
Dec 31 - Jan 1, 2026
Total with taxes and fees
Close to Mayo & Shops, 1 step entry CoveredByFaith

Lux 3 BR mins to Mayo & Dwtwn I Charming Haven

Lux 3 BR mins to Mayo & Dwtwn I Charming Haven
2.0 star property
Rochester
10.0 out of 10, Exceptional, (6)
"This property had everything we needed. Super cute and simple decor, comfortable beds and clean. We would stay here again!! "
United States
Anonymous traveler
$388 nightly
The price is $444
Jan 2 - Jan 3, 2026
Total with taxes and fees
Lux 3 BR mins to Mayo & Dwtwn I Charming Haven

Hart House // One Bed, 1 Ba, St Mary's Mayo Clinic from the Front Porch

Hart House // One Bed, 1 Ba, St Mary's Mayo Clinic from the Front Porch
Kutzky Park
10.0 out of 10, Exceptional, (4)
"Fun neighborhood good bars and restaurants "
United States
David M.
$179 nightly
The price is $207
Jan 4 - Jan 5, 2026
Total with taxes and fees
Hart House // One Bed, 1 Ba, St Mary's Mayo Clinic from the Front Porch

1 mile Mayo 2 step entry Encourage Covered ByFaith

1 mile Mayo 2 step entry Encourage Covered ByFaith
2.0 star property
Parkway
$192 nightly
The price is $221
Dec 30 - Dec 31
Total with taxes and fees
1 mile Mayo 2 step entry Encourage Covered ByFaith

3 blk St Mary 11 Mayo Pet Friendly Covered ByFaith

3 blk St Mary 11 Mayo Pet Friendly Covered ByFaith
Folwell
9.6 out of 10, Exceptional, (25)
"Very clean and ready for us to stay when we arrived."
United States
David L.
$206 nightly
The price is $237
Dec 30 - Dec 31
Total with taxes and fees
3 blk St Mary 11 Mayo Pet Friendly Covered ByFaith

The Cozy Hideaway - 5-Minute Drive to Mayo Clinic

The Cozy Hideaway - 5-Minute Drive to Mayo Clinic
Northrup
9.0 out of 10, Wonderful, (4)
"Perfect place to stay if needing to be close to Mayo. "
United States
Andrea S.
$209 nightly
The price is $241
Jan 4 - Jan 5, 2026
Total with taxes and fees
The Cozy Hideaway - 5-Minute Drive to Mayo Clinic

Across St. to St Mary hospital Covered By Faith 2

Across St. to St Mary hospital Covered By Faith 2
2.0 star property
Kutzky Park
8.0 out of 10, Very Good, (1)
"Easy check in/ Secure entry system "
United States
Ann R.
$133 nightly
The price is $153
Dec 31 - Jan 1, 2026
Total with taxes and fees
Across St. to St Mary hospital Covered By Faith 2
Lowest nightly price found within the past 24 hours based on a 1 night stay for 2 adults. Prices and availability subject to change. Additional terms may apply.
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Top Wykoff Hotel Reviews

Find out more about Wykoff

Everything you need to know about Wykoff vacation rentals

Whether you’re excited for the perfect family vacation, a romantic getaway for two, or the ultimate city break, we’ve got the Wykoff vacation rental for you. At Expedia, you can take your pick from private vacation homes, apartments, condos, resorts, cabins, villas, motels. The list goes on, and on …and on.

There’s just as wide a choice of amenities, too. Maybe you’re dreaming of your own pool, long evenings in a hot tub, or watching the kids laugh through the day at a waterpark. Maybe you just want a quiet retreat in a pet-friendly apartment. Well, we can help you find it. Hunt out the perfect Wykoff vacation rental for you by simply entering your desired dates. Then check your favorite filters to narrow down your search.

Wykoff vacation rentals: An excellent choice for every season

Whenever you want to travel, a warm welcome awaits you in Wykoff. If you’re looking for a little peace, consider booking during the quieter low season months. For more hustle and bustle, you may prefer to visit Wykoff in high season.

Prices vary throughout the year. Your chosen location, property type, and amenities will impact the cost of your trip, too. The selection of properties we have chosen for you start as low as $127 per night. Rates vary depending on your travel dates, location, and amenities so make a search and you might find even better deals!

How to find incredible deals on Wykoff rentals

At Expedia, we put the best Wykoff vacation rentals in one place. All you need to do is take your pick. And as we offer book now, pay later options, as well as free cancellation on some properties, you can plan your trip with total peace of mind. You’ll always find a great deal with Expedia.

To find some top Wykoff rental deals, enter your travel dates, and sort your search results by price. You can also filter by budget, so you only see accommodation in your ballpark. Next, add any filters you want—and just like that, you’ve built your dream Wykoff vacation.

If you’re looking for a little inspiration, browse our latest incredible offers, or use the map to view all accommodation in and around Wykoff. And to unlock even more fantastic deals, bundle your accommodation, flights, and car rental together to save and book with Expedia in complete confidence.

Frequently asked questions

Can I find a vacation rental in Wykoff?

Yes, we offer vacation rentals close to well known sights in Wykoff, or you can select a more secluded option if you're looking for relaxation. Wykoff is known for its museums.

What are some of the best vacation home rentals in Wykoff?

Clean, fun, comfy ranch home near parks, 2.5 mi to Mayo w Pingpong and Playroom: This vacation home rental outside of Wykoff offers a patio, a garden, and a barbecue grill to help you feel perfectly comfortable in your new surroundings. It has 3 bedrooms as well as a kitchen with a dishwasher, a fridge, and a stovetop, so you can cook with friends or family. Make the most of the selection of games in this rental home to help you unwind.

What’s there to see and do in Wykoff?

Enjoy the area's cultural attractions such as Ed's Museum, or get outdoors into nature at a spot like Forestville Mystery Cave State Park. In the larger area, you’ll find Four Daughters Vineyard & Winery and Deer Creek Speedway.

What’s a vacation rental in Wykoff like?

Vacation rentals are privately owned properties you can book for a few weeks or just a few days in Wykoff. Vacation rentals offer amenities like kitchens and laundry facilities so you'll feel right at home. If you're concerned about a clean environment, a vacation rental can offer a sense of privacy away from shared hotel elevators and busy lobbies while still allowing you a great travel experience. You'll also find more space in a vacation rental than in a hotel, which makes a vacation rental an attractive choice for a family trip or a small group gathering.