
Popular airlines from McGhee Tyson Airport (TYS) to San Francisco Intl. Airport (SFO)
- Delta
Delta
- American Airlines
American Airlines
- United
United
- Frontier Airlines
Frontier Airlines
- Alaska Airlines
Alaska Airlines
- Plan, book, fly with confidence
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Cheap Flights from Knoxville to San Francisco (TYS-SFO)
Prices were available within the past 7 days and start at $144 for one-way flights and $268 for round trip, for the period specified. Prices and availability are subject to change. Additional terms apply.










Find the cheapest month to fly from Knoxville (TYS) to San Francisco (SFO)
November is typically the cheapest month to fly
Graph displaying average flight prices per month
Alternative airports near San Francisco
Prices were available within the past 7 days. Prices and availability are subject to change.
Origin airport | McGhee Tyson |
Destination airport | San Francisco Intl. |
Airlines serving | Alaska Airlines, American Airlines, Delta, Frontier Airlines, United |
Roundtrip price | $268 |
Distance | 2115 mi |
Knoxville to San Francisco Flights
The cheapest times to fly from Knoxville to San Francisco
On average, Thursday can be the cheapest time to fly, according to data from the Airlines Reporting Corporation (ARC), one of the world's biggest databases for global airline sales. The data reveals that you could save up to 16% by flying on a Thursday—the cheapest day to travel on average—instead of a Sunday—the most expensive. Some of the most affordable flights from Knoxville to San Francisco are during the month of August. You can find some of the cheapest flights from Knoxville to San Francisco with Expedia's search tool and vast selection of airlines.
The best time to book a flight from Knoxville to San Francisco
Sunday is one of the best days to book for cheap flights from Knoxville to San Francisco: Tickets reserved on a Sunday cost between 6% and 13% less than those reserved on a Friday, according to ARC data. The data also suggests booking early can also lead to cheaper airfares. You could save 24% by buying your tickets for domestic flights at least a month in advance and 10% by booking international flights 2 months in advance.
How to find cheap round-trip tickets from Knoxville to San Francisco
Being flexible with your dates and using Expedia's Price Drop Protection and Price Tracking features are some of the best ways of finding a cheap ticket from Knoxville to San Francisco in 2025. You can also book with separate airlines for your outbound and return journeys, from $144 one-way. Expedia also offers Price Drop Protection, so if the cost of your airfare goes down after booking, you'll receive a credit for the difference*. This is available for a small fee, and is free to One Key Gold and Platinum tier members.
Expedia's Price Tracking feature means you can stay on top of airfares without manually checking every day. It sends you automated price alerts for cheap Knoxville to San Francisco flights and uses historical data to indicate when the best time to book is. Download Expedia's free app to activate this handy tool in a few easy taps.
You could also save big by booking one of Expedia's vacation packages. Bundling together your Knoxville to San Francisco airfare with your accommodations and car rental is often cheaper than booking everything separately. There’s also One Key, Expedia's generous rewards program. Join for free and you could earn One Key cash on most bookings to save on future adventures.
*Terms apply.
Disclaimer: ARC The statistics are based on average round-trip ticket prices between January and August 2023. The percentages you see are averages.
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Top Routes from Knoxville
- Knoxville to Chicago (TYS - ORD)
- Knoxville to Newark Liberty Intl. Airport (TYS - EWR)
- Knoxville to Phoenix (TYS - PHX)
- Knoxville to San Diego (TYS - SAN)
- Knoxville to Los Angeles (TYS - LAX)
- Knoxville to Miami (TYS - MIA)
- Knoxville to New York (TYS - LGA)
- Knoxville to Fort Lauderdale (TYS - FLL)
- Knoxville to Honolulu (TYS - HNL)
- Knoxville to Boston (TYS - BOS)
- Knoxville to Denver (TYS - DEN)
- Knoxville to New York (TYS - JFK)
Top Routes to San Francisco
- Chicago to San Francisco (ORD - SFO)
- Newark Liberty Intl. Airport to San Francisco (EWR - SFO)
- San Diego to San Francisco (SAN - SFO)
- Phoenix to San Francisco (PHX - SFO)
- Los Angeles to San Francisco (LAX - SFO)
- Washington to San Francisco (DCA - SFO)
- Portland to San Francisco (PDX - SFO)
- New York to San Francisco (LGA - SFO)
- Boston to San Francisco (BOS - SFO)
- Orange County to San Francisco (SNA - SFO)
- Washington to San Francisco (IAD - SFO)
- New York to San Francisco (JFK - SFO)
Top Routes from Knoxville
- American Airlines Knoxville to Chicago
- United Knoxville to Newark Liberty Intl. Airport
- Delta Knoxville to Phoenix
- Alaska Airlines Knoxville to San Diego
- Delta Knoxville to Los Angeles
- American Airlines Knoxville to Miami
- Delta Knoxville to New York
- American Airlines Knoxville to Fort Lauderdale
- United Knoxville to Honolulu
- American Airlines Knoxville to Boston
Top Routes to San Francisco
- Alaska Airlines Chicago to San Francisco
- Alaska Airlines Newark Liberty Intl. Airport to San Francisco
- Alaska Airlines San Diego to San Francisco
- Alaska Airlines Phoenix to San Francisco
- Alaska Airlines Los Angeles to San Francisco
- Alaska Airlines Washington to San Francisco
- Alaska Airlines Portland to San Francisco
- Alaska Airlines Boston to San Francisco
- Alaska Airlines Orange County to San Francisco
- Alaska Airlines Washington to San Francisco
Top Flight Destinations
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Nearby Airports
- Asheville Regional Airport (AVL)
- Chattanooga Metropolitan Airport (CHA)
- Tri-Cities Regional Airport (TRI)
- Greenville-Spartanburg Intl. Airport (GSP)
- Virginia Highlands Airport (VJI)
- DeKalb-Peachtree Airport (PDK)
- Smyrna Airport (MQY)
- Fulton County Airport (FTY)
- Pike County - Hatcher Field Airport (PVL)
- Nashville Intl. Airport (BNA)
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