The Best Hotels Closest to Buffalo Museum of Science in Buffalo for 2026

A large mammoth skeleton in a museum with classical architecture.

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Our top choices for Buffalo Museum of Science hotels

A spacious room with a wooden floor, a fireplace, a dining table, and several chairs.

A historic building with a prominent tower and a traditional brick facade.

A room with a textured ceiling, a chandelier, and walls painted in a two-tone color scheme.

A traditional living room with a green sofa, a wooden coffee table with books, a blue armchair, and various potted plants.

1. Buffalo Harmony House

Allentown, 2 mi from Buffalo Museum of Science

John

$320 nightly

$366 total

Nov 24 - Nov 25

Total with taxes and fees

A grand staircase with ornate woodwork and a chandelier, leading to a room with a large wooden door and a stained glass window.

A room with a red patterned sofa, wooden bookshelves, a chandelier, and a traditional wooden coffee table.

A large, two-story building with a prominent entrance, multiple windows, and a well-maintained garden.

A grand room with a chandelier, a fireplace, and ornate furniture.

2. InnBuffalo off Elmwood

Elmwood Village, 1.8 mi from Buffalo Museum of Science

Terese

$138 nightly

$158 total

Nov 9 - Nov 10

Total with taxes and fees

A two-story building with a white exterior, a red door, and large windows.

A living room with a fireplace, a chandelier, leather sofas, and a glass coffee table.

A spacious living area with a granite island, wooden chairs, a fireplace, and a television.

A living room with a fireplace, leather sofa, and a television mounted on the wall.

3. Buffalo Guesthouse

Allentown, 1.5 mi from Buffalo Museum of Science

Jose

$148 nightly

$170 total

Oct 26 - Oct 27

Total with taxes and fees

A grand entrance with a staircase leading to a door, surrounded by lush greenery and a well-maintained garden.

A pool table in a room with dark walls, large windows, and green upholstered chairs.

A bar area with wooden furniture, a large wooden cabinet, and a clock on the wall.

A pool table in a room with patterned carpet, a dining table with chairs, and a red sofa.

4. The Mansion On Delaware Ave

Allentown, 1.8 mi from Buffalo Museum of Science

Marilyn

$201 nightly

$230 total

Nov 23 - Nov 24

Total with taxes and fees

A modern hotel lobby with a bar area, seating, and a large TV screen.

A modern restaurant with a long counter, bar stools, and a refrigerated display.

A modern hotel lobby with seating areas, a flat-screen TV, and a bookshelf.

A modern indoor swimming pool with clear blue water, surrounded by lounge chairs and a glass-enclosed area.

5. Residence Inn by Marriott Buffalo Downtown

Allentown, 1.6 mi from Buffalo Museum of Science

Karen

$212 nightly

$247 total

Nov 22 - Nov 23

Total with taxes and fees

A spacious lobby with a large sofa, a coffee table, and potted plants. There is a decorative wall with a painting and a large window providing natural light.

A multi-story hotel with a modern facade, large windows, and a covered entrance area.

A compact kitchen with wooden cabinets, a black refrigerator, a microwave, and a coffee maker.

A modern lobby with a sofa set, coffee table, potted plants, and a large window providing natural light.

6. Wyndham Garden Buffalo Downtown

Downtown Buffalo, 1.2 mi from Buffalo Museum of Science

Sara

$158 nightly

$184 total

Oct 25 - Oct 26

Total with taxes and fees

A hotel room with a bed, desk, chair, TV, and a bathroom with a sink and mirror.

A modern kitchen with a central island, bar stools, and various appliances.

A hotel lobby with a curved reception desk, a chandelier, a seating area with leather chairs, and a tiled floor.

A modern hotel lobby with a round coffee table, two grey armchairs, a TV, and a reception desk.

7. Best Western on the Avenue

Allentown, 1.7 mi from Buffalo Museum of Science

Elise

$152 nightly

$178 total

Nov 16 - Nov 17

Total with taxes and fees

A hotel room with a bed, a TV, a desk, a chair, and a sofa.

A gym with exercise equipment, a mirror, and a television.

A hotel room with a flat-screen TV, a wooden dresser, a blue sofa, a small table, and a kitchenette with a coffee maker.

A coffee station with two coffee makers, a coffee dispenser, and various coffee cups and containers.

8. Holiday Inn Express & Suites Buffalo Downtown - Medical CTR by IHG

Buffalo Theater District, 1.9 mi from Buffalo Museum of Science

Sarah

$118 nightly

$138 total

Nov 16 - Nov 17

Total with taxes and fees

A rooftop terrace with wicker furniture, a bar area, and a view of the cityscape.

A modern hotel with a glass facade, multiple floors, and a prominent 'Aloft' sign.

A modern living room with a large window, a flat-screen TV, a sofa, a coffee table, and a patterned rug.

A modern cafe with round tables and chairs, a bar area, and a neon sign.

9. Aloft by Marriott Buffalo Downtown

Buffalo Theater District, 1.9 mi from Buffalo Museum of Science

Anthony T

$179 nightly

$209 total

Nov 8 - Nov 9

Total with taxes and fees

A dining area with a wooden table set for four, surrounded by chairs. There is a kitchen area with cabinets and appliances in the background.

A bedroom with a bed, bedside lamps, a nightstand, a window with curtains, and wall art.

A modern living room with a sectional sofa, a dining area, and a kitchen in the background.

A kitchen with wooden cabinets, a dishwasher, and a dining area with a table and chairs.

10. 4 Mi to Dtwn: Family Home in Buffalo

Masten Park, 0.9 mi from Buffalo Museum of Science

$458 nightly

$526 total

Oct 26 - Oct 27

Total with taxes and fees

A buffet setup with various food items and utensils.

A hotel room with a large bed, a desk with a chair, a bathroom with a bathtub, and a mirror.

A building with a large illuminated sign reading "Russells STEAKS - CHOPS - AND MORE".

A hotel reception desk with a large mirror, a chandelier, and a 'HOTEL' sign.

11. Salvatores Grand Hotel

8.1 mi from Buffalo Museum of Science

Mary

$169 nightly

$192 total

Oct 25 - Oct 26

Total with taxes and fees

A hotel with a prominent entrance, a clock tower, and the name "REIKART HOUSE" displayed above the entrance.

An outdoor patio area with tables and chairs, string lights, and greenery.

A spacious living area with a fireplace, a large sofa, and a dining area with a table and chairs.

A spacious dining area with high ceilings, large windows, and modern chandeliers.

12. Reikart House, Buffalo, a Tribute Portfolio Hotel

5.2 mi from Buffalo Museum of Science

Jonathon

$233 nightly

$265 total

Nov 15 - Nov 16

Total with taxes and fees

13. Hampton Inn Buffalo - Amherst, NY

6.6 mi from Buffalo Museum of Science

Warren

$109 nightly

$124 total

Nov 12 - Nov 13

Total with taxes and fees

A lobby with teal armchairs, a round table, a flat-screen TV, and a stone wall with a fireplace.

A modern lounge area with sofas, round tables, and a stone accent wall.

A hotel with a brick facade, multiple balconies, and a sign for 'The Mosey Hotel & Residences'.

14. The Mosey Buffalo Williamsville, Tapestry Collection by Hilton

5.6 mi from Buffalo Museum of Science

Andres

$166 nightly

$189 total

Nov 8 - Nov 9

Total with taxes and fees

A modern hotel room with a large window, a sofa, a coffee table, and a TV.

A modern kitchen with a central island, bar stools, and built-in appliances.

A hotel lobby with a seating area, dining tables, and large windows offering views of the cityscape.

A modern hotel lobby with a reception desk, seating area, and a large window offering a view of the city.

15. Buffalo Marriott at LECOM HARBORCENTER

Downtown Buffalo, 2.8 mi from Buffalo Museum of Science

Stephen

$251 nightly

$293 total

Nov 8 - Nov 9

Total with taxes and fees

A breakfast buffet with various food items and beverages, a large window with a view of buildings, and a patterned floor.

A heated outdoor swimming pool with lounge chairs and a bar area, surrounded by brick walls and a balcony with decorative lighting.

A modern bar area with a curved counter, leather bar stools, and a large chandelier.

16. Curtiss Hotel, an Ascend Collection Hotel

Buffalo Theater District, 2.1 mi from Buffalo Museum of Science

John

$254 nightly

$297 total

Nov 23 - Nov 24

Total with taxes and fees

A large indoor swimming pool with clear blue water, surrounded by lounge chairs and a sauna area.

A hotel lobby with a seating area featuring sofas, ottomans, and tables. A reception desk and a bar are visible in the background.

A modern hotel room with a large bed, a desk, a TV, and a view of the outdoors.

A multi-story hotel with a prominent entrance, large windows, and a well-lit facade.

17. Hampton Inn Buffalo-Williamsville

6 mi from Buffalo Museum of Science

Robert

$158 nightly

$180 total

Nov 15 - Nov 16

Total with taxes and fees

A spacious lobby with modern furniture, large windows, and a high ceiling with exposed beams.

A gym with treadmills and a rowing machine, large windows, and a city view.

A spacious lobby with a stone fireplace, comfortable seating, large windows, and a modern design.

An outdoor patio area with seating, a fire feature, and a glass-enclosed space with greenery.

18. The Westin Buffalo

Buffalo Theater District, 2.1 mi from Buffalo Museum of Science

Sarah

$254 nightly

$297 total

Oct 29 - Oct 30

Total with taxes and fees

A historic building with a symmetrical facade, large arched windows, and a prominent central entrance.

A spacious lobby with a long reception desk, multiple chandeliers, and a staircase leading to upper floors.

A hallway with a chandelier, an exit sign, and a large window at the end.

19. The Richardson Hotel

Elmwood Bidwell, 2.5 mi from Buffalo Museum of Science

Nayara

$161 nightly

$188 total

Nov 9 - Nov 10

Total with taxes and fees

A spacious lobby with high ceilings, a grand staircase, and a gift shop.

A bar area with red upholstered bar stools, a bar counter, and a chandelier.

A multi-story hotel with a stone facade, a prominent entrance with a metal archway, and a parking lot in front.

A bar area with leather barstools, a bar counter, and a television screen.

20. The Delavan Hotel & Spa

7.7 mi from Buffalo Museum of Science

Tiffany

$116 nightly

$132 total

Nov 3 - Nov 4

Total with taxes and fees

View all properties

Compare popular hotels close to Buffalo Museum of Science

Property	Star rating	Guest rating
Buffalo Harmony House	10.0 Exceptional 56 reviews	View
InnBuffalo off Elmwood	10.0 Exceptional 225 reviews	View
Buffalo Guesthouse	9.4 Exceptional 225 reviews	View
The Mansion On Delaware Ave	9.4 Exceptional 1,001 reviews	View
Residence Inn by Marriott Buffalo Downtown	9.2 Wonderful 390 reviews	View

Top Buffalo Museum of Science Hotel Reviews

Buffalo Guesthouse

10/10 Excellent

"Excellent location and service."

Lenox Hotel and Suites

10/10 Excellent

"Clean room and historic hotel. Friendly staff and good location."

Wyndham Garden Buffalo Downtown

10/10 Excellent

"The staff was so incredibly sweet. The hotel is clean and super comfortable. I would love to stay again."

Best Western on the Avenue

10/10 Excellent

"Very clean and close to great restaurants and bars."

Holiday Inn Express & Suites Buffalo Downtown - Medical CTR by IHG

10/10 Excellent

"Great"

Nice house with king bed 25min to Niagara falls

10/10 Excellent

"Great house for a weekend get away! Host was very responsive with questions and the overall checkin process"

Elmwood Village home

8/10 Good

"Classic Buffalo turn of the century home. Very clean inside. Second bathroom down the stairs outside of the apartment. Three comfy beds but one not as great. Place doesn't look impressive on the outside but quite nice on the inside.Host was very responsive to some minor issues that arose."

Stunning Elmwood Village Lower

10/10 Excellent

"Tv system would not let us see bills game"

Home away from home!

10/10 Excellent

"We will definitely be back to stay. Sandi’s place was perfect, a true home away from home! She is a wonderful host and we enjoyed our stay. The location is on a quiet street, so peaceful."

Other attractions near Buffalo Museum of Science

Buffalo Central Terminal

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Johnnie B. Wiley Sport Pavilion

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Paul Robeson Theater

Enjoy a show at Paul Robeson Theater, a theater with a story to tell in Buffalo. Experience the area's entertainment choices and great live music.

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African American Cultural Center

Enjoy a stop at African American Cultural Center, an entertaining place to visit in Buffalo. Experience the area's acclaimed theater scene and great live music.

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Broadway Market

You can enjoy retail therapy at Broadway Market during your stay in Buffalo. Experience the area's acclaimed theater scene and great live music.

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Koessler Athletic Center

Catch an event at Koessler Athletic Center during your trip to Buffalo.

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Montante Cultural Center

Enjoy an outing to Montante Cultural Center during your stay in Buffalo.

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Hellenic Orthodox Church of the Annunciation

After visiting Hellenic Orthodox Church of the Annunciation, make a plan to see the other sights and activities in Buffalo.

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Frequently asked questions

What are the top-rated hotels near Buffalo Museum of Science?

For those looking to explore the Buffalo Museum of Science, there are top-rated hotels nearby that promise an exceptional stay.InnBuffalo off ElmwoodInnBuffalo off Elmwood is a charming Victorian hotel rated 10 by travelers, located just 2.6 miles from the Buffalo Museum of Science. Guests can enjoy unique amenities such as designer toiletries and a deep soaking bathtub. The hotel features self-parking and offers a free daily breakfast, along with a cozy fireplace and furnished balconies, making it a perfect retreat for those seeking comfort and style.Buffalo Harmony HouseBuffalo Harmony House, with a stellar review rating of 10 and a 4.5-star rating, is situated only 2.4 miles from the Buffalo Museum of Science. This romantic getaway features a private hot tub and beautiful gardens. Guests will appreciate the complimentary full breakfast, as well as the cozy fireplace and daily housekeeping services, all designed to provide a luxurious and relaxing experience.Carriage House Loft - King Bed and Garage ParkingThe Carriage House Loft offers a unique stay just 2.9 miles from the Buffalo Museum of Science, a perfect travelers' rating of 10. This historic hotel comes with a fully equipped kitchen, including an oven, dishwasher, and refrigerator, ideal for those who prefer a home-like experience. Guests enjoy the convenience of onsite garage parking and nearby shopping, making it a practical choice for extended stays.

How much is a hotel near Buffalo Museum of Science?

Staying near Buffalo Museum of Science is a treat, with plenty of hotels from $124 offering incredible amenities. If you're leaning toward a little luxury, prices can rise, especially in peak season. Be sure to book in advance to enjoy more options and potentially better rates, especially if you're planning a vacation during weekends or around public holidays.

What are the most popular family-friendly hotels near Buffalo Museum of Science?

For families looking for an enjoyable stay near Buffalo Museum of Science, several top-rated hotels offer family-friendly amenities and comfortable accommodations.Curtiss Hotel, Ascend Hotel CollectionCurtiss Hotel, Ascend Hotel Collection is a luxurious 5-star hotel located just 2.4 miles from Buffalo Museum of Science, an impressive travelers' rating of 9.2. This family-friendly hotel features connecting rooms, a travel crib, and children's meals at the on-site restaurant, ensuring a comfortable stay for families. Guests also enjoy amenities such as a full-service spa, hot springs, and complimentary breakfast, making it a perfect choice for relaxation after a day of exploring.Hilton Garden Inn Buffalo DowntownHilton Garden Inn Buffalo Downtown, rated 8.6 by travelers, is located just 2.5 miles from Buffalo Museum of Science. This 3-star hotel is perfect for families, offering amenities such as free cribs, connecting rooms, and a kids' menu at the restaurant. Guests can also enjoy the indoor pool and fitness facilities, along with convenient access to a grocery store, ensuring a pleasant and enjoyable stay for the entire family.Hampton Inn & Suites Buffalo DowntownHampton Inn & Suites Buffalo Downtown is a welcoming hotel situated 2.4 miles from Buffalo Museum of Science, with a solid review rating of 8.8. Families will appreciate the kitchenette in rooms, free cribs, and the option for rollaway beds, catering to their needs. The indoor accessible pool, buffet breakfast, and nearby parking further enhance the convenience and comfort for travelers, making it an ideal spot for family trips.

Are there any 5-star hotels near Buffalo Museum of Science?

Discover the top-rated 5-star hotels near Buffalo Museum of Science that promise an exquisite experience during your stay.Curtiss Hotel, Ascend Hotel CollectionCurtiss Hotel, Ascend Hotel Collection, rated 9.2 by travelers, is a luxurious 5-star hotel situated just 2.4 miles from Buffalo Museum of Science. Guests will appreciate the onsite spa offering a variety of treatments, including Swedish and deep tissue massages, alongside a range of hot springs to unwind after a day of exploration. The hotel features exquisite amenities such as Frette Italian sheets, a rooftop terrace, and complimentary breakfast options, ensuring a comfortable and indulgent stay.

Which hotels near Buffalo Museum of Science offer the best views?

Discover the top-rated hotels near Buffalo Museum of Science that offer stunning views and a memorable stay in Buffalo, New York.Buffalo Marriott at LECOM HARBORCENTERBuffalo Marriott at LECOM HARBORCENTER is a 3.5-star hotel located just 3.0 miles from the Buffalo Museum of Science, with an impressive review rating of 9.4. This waterfront hotel features stunning lake views that travelers can enjoy from various rooms and common areas. The hotel amenities include convenient valet parking, a fitness center, and daily housekeeping. With suites available and a snack bar on-site, it caters to both relaxation and convenience for travelers.The Richardson HotelThe Richardson Hotel, rated 9.0 by travelers, is a charming 3.5-star option located 3.5 miles from the Buffalo Museum of Science. Nestled in a historical district, this hotel offers a picturesque resort view and a serene garden for travelers to unwind. Key amenities include a 24-hour fitness facility, daily housekeeping, and self-parking, ensuring a comfortable stay. With its unique blend of history and modern comforts, it presents a delightful experience for those exploring Buffalo.

What are the best affordable hotels near Buffalo Museum of Science?

Discover the best affordable hotels near Buffalo Museum of Science, perfect for family-friendly stays and budget-conscious travelers.InnBuffalo off ElmwoodInnBuffalo off Elmwood, just 2.6 miles from Buffalo Museum of Science, is a charming Victorian hotel with a perfect travelers' rating of 10. This delightful stay offers complimentary breakfast daily, free WiFi, and a relaxing atmosphere with designer toiletries. Guests can enjoy additional amenities like a billiards table, yoga classes onsite, and the option for early check-in, making it an ideal choice for families seeking comfort and convenience.Carriage House Loft - King Bed and Garage ParkingThe Carriage House Loft - King Bed and Garage Parking is located 2.9 miles from Buffalo Museum of Science and is rated 10 by travelers. This historic loft features a fully equipped kitchen with a dishwasher and oven, perfect for families wanting to prepare their own meals. Guests also appreciate the convenience of onsite garage parking and nearby duty-free shopping, ensuring a comfortable and enjoyable stay.Summer Street Guest HouseSummer Street Guest House, positioned just 2.2 miles from Buffalo Museum of Science, boasts a strong travelers' rating of 10 and a 3-star designation. This traveler house offers essential amenities such as free WiFi and self-parking, making it a practical choice for families. Guests can unwind in the patio area or make use of the in-room kitchen facilities, creating a cozy home-away-from-home atmosphere.

Are there any hotels with pools close to Buffalo Museum of Science?

Looking for top-rated hotels with pools near Buffalo Museum of Science? Here are some excellent options that offer both relaxation and family-friendly amenities.Quality Inn Near Walden Galleria MallQuality Inn Near Walden Galleria Mall is a welcoming choice just 4.6 miles from Buffalo Museum of Science, featuring an indoor pool accessible for all travelers. Rated 8.0 by travelers, this hotel provides family-friendly amenities such as free cribs and daily continental breakfast. Guests can also enjoy free parking and a fitness center, making it a convenient stay for families.M Hotel BuffaloM Hotel Buffalo is situated 4.6 miles from Buffalo Museum of Science and holds a 3.5-star rating with a review rating of 7.4. This hotel features an indoor pool that is accessible for all travelers. Families will appreciate the free breakfast and on-site shopping mall, along with free parking and a scheduled airport shuttle service.Aloft Buffalo DowntownAloft Buffalo Downtown, located only 2.1 miles from Buffalo Museum of Science, is a stylish 3-star hotel an inviting indoor pool. With a review rating of 8.2, it offers features such as free breakfast and a 24-hour fitness center. Guests can also enjoy accessibility options, a billiards table, and evening entertainment, providing a vibrant atmosphere for families.

What are the best pet-friendly hotels near Buffalo Museum of Science?

Finding the perfect pet-friendly stay near Buffalo Museum of Science is easy with these top-rated options that welcome your furry friends.Home2 Suites by Hilton Buffalo Airport / Galleria MallHome2 Suites by Hilton Buffalo Airport / Galleria Mall is a 3-star hotel located just 4.8 miles from Buffalo Museum of Science, featuring a great traveler rating score of 9.0. This hotel is ideal for travelers with pets, offering pet-friendly amenities including food and water bowls and a welcoming atmosphere for dogs and cats. Guests can enjoy a range of amenities such as a free buffet breakfast, an indoor pool, and a fitness center, ensuring a comfortable and enjoyable stay.Hampton Inn & Suites Buffalo DowntownHampton Inn & Suites Buffalo Downtown is a comfortable option located just 2.4 miles from Buffalo Museum of Science, with an impressive review rating of 8.8. This pet-friendly hotel welcomes dogs and cats, providing food and water bowls for their convenience. Guests can enjoy amenities such as a free buffet breakfast, an indoor pool, and a rooftop garden, perfect for relaxation after a day of exploring.Aloft Buffalo DowntownAloft Buffalo Downtown is a stylish 3-star hotel situated only 2.1 miles from Buffalo Museum of Science, with a solid review rating of 8.2. This pet-friendly hotel allows pets in-room and offers complimentary amenities like food and water bowls. Guests can take advantage of the indoor pool, 24-hour fitness facilities, and a vibrant atmosphere with evening entertainment, making it a great choice for both travelers and their furry companions.

Can I book a fully refundable hotel close to Buffalo Museum of Science?

Most bookings on Expedia are refundable if canceled within 24-48 hours of arrival, though this depends on the hotel's individual cancellation policy, which you should check in your booking confirmation. If free cancellation is available, you can cancel directly through your Expedia account by going to "My Trips" and selecting your reservation. To find fully refundable hotel options, simply enter "Buffalo Museum of Science", set your travel dates, and use the "Fully refundable" filter under "Deals & Discounts" on the results page. Alternatively, explore deals with free cancellation options on Expedia.

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Things to do in Buffalo

Find hotels near Buffalo Museum of Science, Buffalo from $124

Upfront pricing

Treat yourself

Be picky

Check prices for these dates

Filter by

Star rating

Guest rating

Our top choices for Buffalo Museum of Science hotels

1. Buffalo Harmony House

2. InnBuffalo off Elmwood

3. Buffalo Guesthouse

4. The Mansion On Delaware Ave

5. Residence Inn by Marriott Buffalo Downtown

6. Wyndham Garden Buffalo Downtown

7. Best Western on the Avenue

8. Holiday Inn Express & Suites Buffalo Downtown - Medical CTR by IHG

9. Aloft by Marriott Buffalo Downtown

10. 4 Mi to Dtwn: Family Home in Buffalo

11. Salvatores Grand Hotel

12. Reikart House, Buffalo, a Tribute Portfolio Hotel

13. Hampton Inn Buffalo - Amherst, NY

14. The Mosey Buffalo Williamsville, Tapestry Collection by Hilton

15. Buffalo Marriott at LECOM HARBORCENTER

16. Curtiss Hotel, an Ascend Collection Hotel

17. Hampton Inn Buffalo-Williamsville

18. The Westin Buffalo

19. The Richardson Hotel

20. The Delavan Hotel & Spa

Compare popular hotels close to Buffalo Museum of Science

Top Buffalo Museum of Science Hotel Reviews

Buffalo Guesthouse

Lenox Hotel and Suites

Wyndham Garden Buffalo Downtown

Best Western on the Avenue

Holiday Inn Express & Suites Buffalo Downtown - Medical CTR by IHG

Nice house with king bed 25min to Niagara falls

Elmwood Village home

Stunning Elmwood Village Lower

Home away from home!

Other attractions near Buffalo Museum of Science

Buffalo Central Terminal

Johnnie B. Wiley Sport Pavilion

Paul Robeson Theater

African American Cultural Center

Broadway Market

Koessler Athletic Center

Montante Cultural Center

Hellenic Orthodox Church of the Annunciation

Frequently asked questions

Explore a world of travel with Expedia