Sikeston, MO

Travel Guide

A tree with sunlight filtering through its leaves, creating a warm glow.
A person walking through a cornfield.
A building with three tall chimneys, surrounded by blooming trees with pink and white flowers.
A sign for Lambert's, a place of worship.
Drury Inn & Suites Sikeston, MO

Drury Inn & Suites Sikeston, MO

3 out of 5
2608 East Malone Ave, Miner Sikeston MO
$111 nightly
The price is $128 total per night from Jul 6 to Jul 7
$128 total
Jul 6 - Jul 7
Total with taxes and fees
Book a stay at this business-friendly hotel in Sikeston. Enjoy free breakfast, free WiFi, and free parking. Our guests praise the breakfast and the helpful staff ...
9.6/10 Exceptional! (1,008 reviews)
"This property is well maintained,very clean, comfy and full of friendly staff!"

Reviewed on Jun 30, 2026

Drury Inn & Suites Sikeston, MO
Days Inn and Suites by Wyndham Sikeston

Days Inn and Suites by Wyndham Sikeston

2 out of 5
220 S Interstate Dr Sikeston MO
$69 nightly
The price is $78 total per night from Jul 13 to Jul 14
$78 total
Jul 13 - Jul 14
Total with taxes and fees
Book a stay at this business-friendly hotel in Sikeston. Enjoy free breakfast, free WiFi, and free parking. Our guests praise the helpful staff and the clean ...
7.2/10 Good! (1,002 reviews)
"The air conditioning was good! But not very clean room. Hair everywhere. Strange fluids on bed and couch. Very spacious. You get what you pay for."

Reviewed on Jun 29, 2026

Days Inn and Suites by Wyndham Sikeston
Best Western Plus Sikeston I-55

Best Western Plus Sikeston I-55

2.5 out of 5
120 S Interstate Drive Sikeston MO
$85 nightly
The price is $97 total per night from Jul 26 to Jul 27
$97 total
Jul 26 - Jul 27
Total with taxes and fees
Stay at this hotel in Sikeston. Enjoy free breakfast, free parking, and a fitness center. Our guests praise the breakfast and the helpful staff in our reviews. ...
8.4/10 Very Good! (1,006 reviews)
"The room was clean. It is a little run down but not too bad at all. Be aware that you have to get a new key everyday. They didn't harass us over needing extra towels the first night but they ran out of towels the second night which is weird."

Reviewed on Jun 29, 2026

Best Western Plus Sikeston I-55
See all 314 properties in Sikeston
Lowest nightly price found within the past 24 hours based on a 1 night stay for 2 adults. Prices and availability subject to change. Additional terms may apply.
New cabin in the woods with private hot tub

New cabin in the woods with private hot tub

Cobden IL
Stay at this cabin in Anna. Enjoy patios, an in-room coffeemaker, and air conditioning. Popular attractions StarView Vineyards and King Neptune Memorial are ...
10/10 Exceptional! (156 reviews)
"This was a beautiful secluded cabin. I enjoyed the privacy and the beautiful drive"

Reviewed on Jun 16, 2026

New cabin in the woods with private hot tub
Brand new cabin in the woods with hot tub 1/2 mile from Starview Winery

Brand new cabin in the woods with hot tub 1/2 mile from Starview Winery

Cobden IL
Stay at this cabin in Anna. Enjoy patios, an in-room coffeemaker, and in-room fireplaces. Popular attractions StarView Vineyards and King Neptune Memorial are ...
10/10 Exceptional! (169 reviews)
"Nice quiet place to stay, very close to the star view winery. 20 minutes from the Giant City lodge and Bald Knob Cross"

Reviewed on Jun 7, 2026

Brand new cabin in the woods with hot tub 1/2 mile from Starview Winery
Notting Hill Cottage

Notting Hill Cottage

Alto Pass IL
Stay at this vacation home in Alto Pass. Enjoy laundry facilities, patios, and an in-room coffeemaker. Popular attractions Peachbarn Winery and Von Jakob Winery ...
9.6/10 Exceptional! (334 reviews)
"The host was great at communicating with us. The hot tub and deck was so nice! Very quiet and peaceful location! We would stay again!"

Reviewed on Jun 13, 2026

Notting Hill Cottage
See all properties in Sikeston
Lowest nightly price found within the past 24 hours based on a 1 night stay for 2 adults. Prices and availability subject to change. Additional terms may apply.

Stay near popular Sikeston attractions

Sikeston Depot Museum

7.6/10 (57 reviews)
You can spend time exploring the galleries in Sikeston Depot Museum in Sikeston. While in this family-friendly area, you can savor the top-notch restaurants.
See properties

Cities near Sikeston

A sunset over a calm lake with tall trees reflected in the water.

Charleston

A tree-lined landscape with a river and fields.

East Prairie

Other places like Sikeston

Explore a world of travel with Expedia