Title: Visit Sikeston: 2026 Travel Guide for Sikeston, Missouri | Expedia.com [Hotels in Sikeston](https://expedia.com/Sikeston-Hotels.d6058766.Travel-Guide-Hotels)[Vacation Rentals in Sikeston](https://expedia.com/Sikeston-Vacation-Rentals.d6058766.Travel-Guide-VacationRentals)[Flights to Sikeston](https://expedia.com/Cheap-Flights-To-Sikeston.d6058766.Travel-Guide-Flights)[Car Rentals in Sikeston](https://expedia.com/Car-Rentals-In-Sikeston.d6058766.Car-Rental-Guide)[Sikeston Vacation Packages](https://expedia.com/Sikeston.d6058766.Destination-Travel-Guides) # Sikeston, MO ## Travel Guide ![Pre-teen girl walking through corn maze during fall](https://images.trvl-media.com/place/6058766/0353751e-5978-48d0-a913-84533caba2b0.jpg?impolicy=fcrop&w=1040&h=580&q=mediumHigh) ![Columns and Dogwood Trees. Columns from an old church surrounded by colorful dog wood trees in full bloom ](https://images.trvl-media.com/place/6058766/eef79b9e-fdd7-4f80-86db-e7371463f21a.jpg?impolicy=fcrop&w=1040&h=580&q=mediumHigh) ![Sikeston](https://images.trvl-media.com/place/553248634983441802/03fb167a-d590-4293-9dd9-648c99605c85.jpg?impolicy=fcrop&w=1040&h=580&q=mediumHigh) ## Visit Sikeston Things to do - Sikeston Hotel Deals - Vacation Rentals in Sikeston ![Drury Inn & Suites Sikeston, MO](https://images.trvl-media.com/lodging/1000000/30000/24300/24210/85184a8e_y.jpg?impolicy=resizecrop&rw=340&ch=150) ### Drury Inn & Suites Sikeston, MO 2608 East Malone Ave, Miner Sikeston MO $108 total per night Apr 5 - Apr 6 Book a stay at this business-friendly hotel in Sikeston. Enjoy free breakfast, free WiFi, and free parking. Our guests praise the breakfast and the helpful staff ... 9.4/10 Exceptional! (1,005 reviews) . Reviewed on Mar 30, 2026 [](https://expedia.com/Hotel-Search?startDate=4%2F5%2F2026&endDate=4%2F6%2F2026&selected=24210&PinnedHotelID=24210&HadPinnedHotel=true®ionId=6058766) ![Hampton Inn Sikeston](https://images.trvl-media.com/lodging/26000000/25180000/25178200/25178175/77525d07_y.jpg?impolicy=resizecrop&rw=340&ch=150) ### Hampton Inn Sikeston 1240 Commerce Drive Sikeston MO $111 total per night Apr 12 - Apr 13 Stay at this hotel in Sikeston. Enjoy free breakfast, free WiFi, and free parking. Our guests praise the helpful staff in our reviews. Popular attractions Central ... 9/10 Wonderful! (519 reviews) The property is deceiving, Chicken sausage on the breakfast buffet But worst of all hair in my shower and as I’m checking out to confirm the hair that had been on my baby’s bottle when it had fell on the floor. A guest left with three large cages full of cats. So these room rooms are allowed to have ... Reviewed on Mar 29, 2026 [](https://expedia.com/Hotel-Search?startDate=4%2F12%2F2026&endDate=4%2F13%2F2026&selected=25178175&PinnedHotelID=25178175&HadPinnedHotel=true®ionId=6058766) ![Best Western Plus Sikeston I-55](https://images.trvl-media.com/lodging/9000000/8430000/8420600/8420572/29a4ab37_y.jpg?impolicy=resizecrop&rw=340&ch=150) ### Best Western Plus Sikeston I-55 120 S Interstate Drive Sikeston MO $106 total per night Apr 5 - Apr 6 Stay at this hotel in Sikeston. Enjoy free breakfast, free parking, and a fitness center. Our guests praise the breakfast and the helpful staff in our reviews. ... 8.4/10 Very Good! (1,001 reviews) Room was clean, breakfast was good, staff was friendly Reviewed on Mar 27, 2026 [](https://expedia.com/Hotel-Search?startDate=4%2F5%2F2026&endDate=4%2F6%2F2026&selected=8420572&PinnedHotelID=8420572&HadPinnedHotel=true®ionId=6058766) [See all 297 properties in Sikeston](https://expedia.com/Hotel-Search?rfrrid=TG.LP.Hotels.DestinationExperience&startDate=3%2F31%2F2026&endDate=4%2F1%2F2026®ionId=6058766) Lowest nightly price found within the past 24 hours based on a 1 night stay for 2 adults. Prices and availability subject to change. Additional terms may apply. ![Brand new cabin in the woods with hot tub 1/2 mile from Starview Winery ](https://images.trvl-media.com/lodging/75000000/74270000/74269700/74269659/ad42e650_y.jpg?impolicy=resizecrop&rw=340&ch=150) ### Brand new cabin in the woods with hot tub 1/2 mile from Starview Winery Cobden IL Stay at this cabin in Anna. Enjoy patios, an in-room coffeemaker, and in-room fireplaces. Popular attractions StarView Vineyards and King Neptune Memorial are ... 10/10 Exceptional! (162 reviews) We loved our stay… wish it could’ve been longer! Loved the outdoor atmosphere… Beautiful woodland area… an especially nice view while relaxing in the hot tub… ( our fav part)… the house was pristine and decorated to match the outdoors! We enjoyed some of Gods beautiful creations by traveling from ... Reviewed on Mar 15, 2026 [](https://expedia.com/Anna-Hotels-Brand-New-Cabin-In-The-Woods-With-Hot-Tub-12-Mile-From-Starview-Winery.h74269659.Hotel-Information) ![Cabin in Southern Illinois - Hot Tub - Romantic Getaway -Shawnee National Forest](https://images.trvl-media.com/lodging/35000000/34340000/34332000/34331993/cb67aaf7_y.jpg?impolicy=resizecrop&rw=340&ch=150) ### Cabin in Southern Illinois - Hot Tub - Romantic Getaway -Shawnee National Forest Jonesboro IL Stay at this cabin in Jonesboro. Enjoy free WiFi, a garden, and patios. Popular attractions Grassy Lake and Union County State Fish and Wildlife Area are located ... 10/10 Exceptional! (279 reviews) It is a very nice place. Quiet and secluded. Very clean and nicely designed and furnished. The rooms are spacious. Kitchen was stocked w utensils, plates, etc. We loved the screened in porch. The hot tub was very refreshing and spacious. Enjoyed the fire pit at night. (Watch for bugs though)For directions; ... Reviewed on Mar 27, 2026 [](https://expedia.com/Jonesboro-Hotels-Cabin-In-Southern-Illinois-Hot-Tub-Romantic-Getaway-Shawnee-National-Forest.h34331993.Hotel-Information) ![Hot Tub - Minutes from Winetrail, SIU, Giant City, Cedar Lake, Shawnee Forest!](https://images.trvl-media.com/lodging/103000000/102840000/102831500/102831406/722821ca_y.jpg?impolicy=resizecrop&rw=340&ch=150) ### Hot Tub - Minutes from Winetrail, SIU, Giant City, Cedar Lake, Shawnee Forest! Makanda IL Book a stay at this golf cabin in Makanda. Enjoy free WiFi, a garden, and laundry facilities. Popular attractions Stone Creek Golf Club and Resort and Makanda ... [](https://expedia.com/Makanda-Hotels-Hot-Tub-Minutes-From-Winetrail.h102831406.Hotel-Information) [See all properties in Sikeston](https://expedia.com/Hotel-Search?rfrrid=TG.LP.Hotels.DestinationExperience®ionId=6058766&sort=VACATION_RENTAL) Lowest nightly price found within the past 24 hours based on a 1 night stay for 2 adults. Prices and availability subject to change. Additional terms may apply. ## Check Sikeston hotel availability [Tonight ](https://expedia.com/Hotel-Search?rfrrid=TG.LP.CheckPrices.DestinationExperience&adults=2&openPlayBack=true®ionId=6058766&startDate=2026-03-30&endDate=2026-03-31)[Mar 30 - Mar 31](https://expedia.com/Hotel-Search?rfrrid=TG.LP.CheckPrices.DestinationExperience&adults=2&openPlayBack=true®ionId=6058766&startDate=2026-03-30&endDate=2026-03-31) [Tomorrow night ](https://expedia.com/Hotel-Search?rfrrid=TG.LP.CheckPrices.DestinationExperience&adults=2&openPlayBack=true®ionId=6058766&startDate=2026-03-31&endDate=2026-04-01)[Mar 31 - Apr 1](https://expedia.com/Hotel-Search?rfrrid=TG.LP.CheckPrices.DestinationExperience&adults=2&openPlayBack=true®ionId=6058766&startDate=2026-03-31&endDate=2026-04-01) [This weekend ](https://expedia.com/Hotel-Search?rfrrid=TG.LP.CheckPrices.DestinationExperience&adults=2&openPlayBack=true®ionId=6058766&startDate=4%2F3%2F2026&endDate=4%2F5%2F2026)[Apr 3 - Apr 5](https://expedia.com/Hotel-Search?rfrrid=TG.LP.CheckPrices.DestinationExperience&adults=2&openPlayBack=true®ionId=6058766&startDate=4%2F3%2F2026&endDate=4%2F5%2F2026) [Next weekend ](https://expedia.com/Hotel-Search?rfrrid=TG.LP.CheckPrices.DestinationExperience&adults=2&openPlayBack=true®ionId=6058766&startDate=4%2F10%2F2026&endDate=4%2F12%2F2026)[Apr 10 - Apr 12](https://expedia.com/Hotel-Search?rfrrid=TG.LP.CheckPrices.DestinationExperience&adults=2&openPlayBack=true®ionId=6058766&startDate=4%2F10%2F2026&endDate=4%2F12%2F2026) ### Popular places to visit #### Sikeston Depot Museum 4/5(15 reviews) You can spend time exploring the galleries in Sikeston Depot Museum in Sikeston. While in this relaxing area, you can savor the top-notch restaurants. [](https://expedia.com/Sikeston-Depot-Museum-Sikeston.d6305602.Vacation-Attraction) #### Central Park 4/5(25 reviews) Explore the great outdoors at Central Park, a lovely green space in Sikeston. While in this relaxing area, you can savor the top-notch restaurants. [](https://expedia.com/Central-Park-Sikeston.d6305608.Vacation-Attraction) #### City of Miner Convention Center Learn about the events happening at City of Miner Convention Center during your trip to Miner. While in this family-friendly area, you can savor the top-notch restaurants. [](https://expedia.com/City-Of-Miner-Convention-Center-Sikeston.d818566100963352576.Vacation-Attraction) ## Cities near Sikeston ![Cypress Trees on the Horizon. A sting of cypress trees of various sizes extend across the horizon as the sunken sun paints the multicolored sky. ](https://images.trvl-media.com/place/7182/2c4b1a06-d3aa-4171-b8b6-0e4eaaa0e80e.jpg?impolicy=fcrop&w=512&h=288&q=medium) ### Charleston ![The Mississippi River near Hannibal, Missouri, USA](https://images.trvl-media.com/place/6209928/2afb9a4b-494b-462a-af23-159cb6a96bb2.jpg?impolicy=fcrop&w=512&h=288&q=medium) ### East Prairie ### Other places like Sikeston ## Explore a world of travel with Expedia - Lodging - Flights - Packages - Cars - Vacation Rentals - [Hotels near Sikeston Depot Museum ](https://www.expedia.com/Sikeston-Depot-Museum-Hotels.0-l6305602-0.Travel-Guide-Filter-Hotels) - [Hotels near Central Park ](https://www.expedia.com/Central-Park-Hotels.0-l6305608-0.Travel-Guide-Filter-Hotels) - [Hotels near Sikeston Memorial Municipal ](https://www.expedia.com/Sikeston-Memorial-Municipal-Airport-Hotels.0-aSIK-0.Travel-Guide-Filter-Hotels) - [The Book Bug ](https://www.expedia.com/The-Book-Bug-Hotels.0-l553248621532655751-0.Travel-Guide-Filter-Hotels) - 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[Flights from Bertrand ](https://www.expedia.com/lp/flights/3000349285/flights-from-bertrand) - [Flights from Blodgett ](https://www.expedia.com/lp/flights/3000349291/flights-from-blodgett) - [Flights from Morley ](https://www.expedia.com/lp/flights/553248634983172137/flights-from-morley) - [Flights from East Prairie ](https://www.expedia.com/lp/flights/3000349349/flights-from-east-prairie) - [Flights to Charleston ](https://www.expedia.com/Cheap-Flights-To-Charleston.d7182.Travel-Guide-Flights) - [Flights from Charleston ](https://www.expedia.com/lp/flights/7182/flights-from-charleston) - [Flights to Oran ](https://www.expedia.com/Cheap-Flights-To-Oran.d3000445386.Travel-Guide-Flights) - [Flights to Bloomfield ](https://www.expedia.com/Cheap-Flights-To-Bloomfield.d6351829.Travel-Guide-Flights) - [Flights from Stoddard County ](https://www.expedia.com/lp/flights/553248635976432323/flights-from-stoddard-county) - [Sikeston Depot Museum ](https://www.expedia.com/Sikeston-Depot-Museum-Sikeston.d6305602.Vacation-Attraction) - [Central Park ](https://www.expedia.com/Central-Park-Sikeston.d6305608.Vacation-Attraction) - [Boot Heel Golf Club ](https://www.expedia.com/Boot-Heel-Golf-Club-Sikeston.d6305606.Vacation-Attraction) - [Visit Bertrand ](https://www.expedia.com/Bertrand.dx3000349285) - [Bertrand Vacations ](https://www.expedia.com/Bertrand.d3000349285.Destination-Travel-Guides) - [Visit Blodgett ](https://www.expedia.com/Blodgett.dx3000349291) - [Visit Canalou ](https://www.expedia.com/Canalou.dx3000349311) - [Visit East Prairie ](https://www.expedia.com/East-Prairie.dx3000349349) - [Charleston Vacations ](https://www.expedia.com/Charleston.d7182.Destination-Travel-Guides) - [Visit Oran ](https://www.expedia.com/Oran.dx3000445386) - [Bloomfield Vacations ](https://www.expedia.com/Bloomfield.d6351829.Destination-Travel-Guides) - [Visit Catron ](https://www.expedia.com/Catron.dx3000349317) - [Car rentals near Miner ](https://www.expedia.com/Car-Rentals-In-Miner.d553248634983441802.Car-Rental-Guide) - [Dollar Europe Rental Cars in Miner ](https://www.expedia.com/Dollar-Europe-Car-Rentals-In-Miner.d553248634983441802-c1090.Car-Rental-Guide-Suppliers) - 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[Sikeston Depot Museum ](https://expedia.com/Sikeston-Depot-Museum-Sikeston.d6305602.Vacation-Attraction) - [Central Park ](https://expedia.com/Central-Park-Sikeston.d6305608.Vacation-Attraction) - [Shawnee National Forest ](https://expedia.com/Shawnee-National-Forest-Illinois.d553248635944113522.Vacation-Attraction) - [Mississippi River ](https://expedia.com/Mississippi-River-United-States-of-America.d6209928.Vacation-Attraction) - [Ohio River ](https://expedia.com/Ohio-River-United-States-of-America.d681940626945888256.Vacation-Attraction) - [Southeast Missouri State University ](https://expedia.com/Southeast-Missouri-State-University-Cape-Girardeau.d553248621554122994.Vacation-Attraction) - [Ohio River Valley ](https://expedia.com/Ohio-River-Valley-United-States-of-America.d6233674.Vacation-Attraction) - [Riverfront Park ](https://expedia.com/Riverfront-Park-Cape-Girardeau.d740677735274594304.Vacation-Attraction) - [Riverfront Bridge Park ](https://expedia.com/Riverfront-Bridge-Park-Cape-Girardeau.d553248621532655774.Vacation-Attraction) - 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