Photo by Skyy

Find 4 Star Hotels in Cape Girardeau, MO from $159

Most hotels are fully refundable. Because flexibility matters.

Save 10% or more on over 100,000 hotels worldwide as a One Key member.

Search over 2.9 million properties and 550 airlines worldwide.

Compare Cape Girardeau 4 Star Hotels with updated room rates, reviews, and availability. Most hotels are fully refundable.

Gold Suite | View from room
Davie School Inn
4.0 star property
10.0 out of 10, Exceptional, (39)
"I don't often leave reviews but this hotel is exceptional. The owner showed me to the room and explained all the facilities. The room itself was huge, beautifully clean and with the wonderful quirk of still resembling a school classroom. Some previous guests had even left messages on the blackboards. I made use of both the Jacuzzi and the separate shower, and enjoyed the cooked breakfast which was brought to my room in the morning. I didn't make use of the complimentary popcorn and DVD selection...
The price is $159
$177 total
includes taxes & fees
May 20 - May 21
Davie School Inn

Cape Girardeau Four Star Hotel Information

When you need to book a room with luxurious amazing amenities and the best rates, the 4 star hotels in Cape Girardeau, Missouri are incredible options. Known for their extra perks, first-rate service, and fantastic locations, each of the Cape Girardeau 4 star hotels offers the ultimate experience for globe-trotting travelers. Relax in your expertly designed room. Kick back with around-the-clock room service.

Get a good night’s sleep with the ultra-plush bedding, and freshen up in the morning with designer-inspired body products. It’s all available when you stay at one of the top book a four star hotels in Cape Girardeau. What’s more, thanks to Expedia you might even score a cheap great deal on a 4 star hotel in Cape Girardeau, Missouri, areas near the hottest attractions, so you can plan a sightseeing adventure and take advantage of unbeatable discounts in one fell swoop.

Whether you’re putting together a serene getaway or want to revel in the most vibrant entertainment district, 4 star Cape Girardeau hotels offer everything your heart desires.

Frequently asked questions

How much does it cost to stay in a 4-star hotel in Cape Girardeau?
To book a 4-star hotel in Cape Girardeau that’s within your budget, use Expedia’s search and sort filters. Browse the availability during your vacation dates and use our pricing filter to set your maximum rate. You can also list your results by the most economical stay first.

  • Search for the lowest price from $159

What's the difference between 5-star and 4-star hotels in Cape Girardeau?
Treat yourself to refined living during your Cape Girardeau getaway by staying at a 4-star hotel. As well as featuring upscale surroundings, these retreats are usually packed with amenities, including large beds, bathrobes and plenty more. A 5-star hotel will go above and beyond to make your stay an even more indulgent and memorable one. 24-hour front desk, luxurious spas and world-class dining are just the start of the superior services and conveniences you’ll likely be able to enjoy.
Does Cape Girardeau have any 4-star all-inclusive resorts?
Enjoy a carefree vacation experience where almost everything is included in the one upfront price by using our “All inclusive” filter. Keeping to your budget is a breeze when your meals, accommodations and activities are already taken care of. Eager for more options? Browse the great deals on our standard 4-star stays in and around Cape Girardeau too.
Are there any 4-star casino hotels in Cape Girardeau?
Use our convenient filters to refine your Cape Girardeau search by amenities, star rating and more. Whether you’re craving a complete casino resort experience or simply want to give your luck a try while living in the lap of 4-star style, you’re sure to find something that strikes the ideal balance between relaxation and entertainment.