Find 4 Star Hotels in Cape Girardeau, MO from $159
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Compare Cape Girardeau 4 Star Hotels with updated room rates, reviews, and availability. Most hotels are fully refundable.
Davie School Inn
Cape Girardeau Four Star Hotel Information
When you need to book a room with luxurious amazing amenities and the best rates, the 4 star hotels in Cape Girardeau, Missouri are incredible options. Known for their extra perks, first-rate service, and fantastic locations, each of the Cape Girardeau 4 star hotels offers the ultimate experience for globe-trotting travelers. Relax in your expertly designed room. Kick back with around-the-clock room service.
Get a good night’s sleep with the ultra-plush bedding, and freshen up in the morning with designer-inspired body products. It’s all available when you stay at one of the top book a four star hotels in Cape Girardeau. What’s more, thanks to Expedia you might even score a cheap great deal on a 4 star hotel in Cape Girardeau, Missouri, areas near the hottest attractions, so you can plan a sightseeing adventure and take advantage of unbeatable discounts in one fell swoop.
Whether you’re putting together a serene getaway or want to revel in the most vibrant entertainment district, 4 star Cape Girardeau hotels offer everything your heart desires.
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Cape Girardeau Hotels by Star Rating
Stay near popular Cape Girardeau attractions
- Southeast Missouri State University
- Isle Casino Cape Girardeau
- Hunter Valley Winery
- Cape Splash Family Aquatic Center
- Riverfront Bridge Park
- Cape Rock Park
- Riverfront Park
- Lazy L Safari Park
- Cape Girardeau Conservation Nature Center
- eDen Spa & Salon
- Fort D Historic Site
- Shawnee National Forest
- Mississippi River
- Giant City State Park
- Trail of Tears State Park
- StarView Vineyards
- Stone Creek Golf Club and Resort
- Pomona Winery
- Owl Creek Vineyard
- Bollinger Mill State Historic Site
More Hotel Options in Cape Girardeau
- Business Hotels (8)
- Casinos (8)
- Cheap Hotels (5)
- Family Hotels (10)
- Historic Hotels (1)
- Hotel Wedding Venues (4)
- Hotels & Resorts for Couples (3)
- Hotels with Air Conditioning (12)
- Hotels with Balconies (1)
- Hotels with Bars (5)
- Hotels with Connecting Rooms (6)
- Hotels with Free Breakfast (8)
- Hotels with Free Parking (10)
- Hotels with Free Wifi (10)
- Hotels with Hot Tubs (5)
- Hotels with Laundry Facilities (9)
- Hotels with Restaurants (10)
- Hotels with Suites (4)
- Hotels with Tennis Courts (2)
- Hotels with a Gym (8)
- Hotels with a Pool (8)
- Hotels with a View (2)
- Hotels with an Indoor Pool (6)
- Hotels with an Outdoor Pool (7)
- Hotels with smoking rooms (2)
- Luxury Hotels (4)
- Non-Smoking Hotels (8)
- Pet-friendly Hotels (7)
- Resorts & Hotels with Spas (3)
- Romantic Hotels (1)
- Winery Hotels (1)
More Accommodation Types in Cape Girardeau
Explore more hotels
- Fairfield Inn & Suites by Marriott Cape Girardeau
- Town House Inn Cape Giradreau
- 4-acre Home with Multiple Decks: Pool Table | Putt-Putt I 4 miles to Downtown
- Serenity South -- Gardens, River-Views, and Refreshing Space
- Charming Secluded Getaway Cabin within minutes of amenities
- Little Blue Cottage on Spanish
- Loft Apartment Across From Semo University Houch Field House. Walk To Events
- Artistic and Creative Vibe with Indoor Swing 2 Blocks to Downtown & near SEMO
- Updated 3 bedroom unit with balcony!
- Charming 2-Story- C.1847 - River Views - Fast Wifi
- La Quinta Inn & Suites by Wyndham Jackson/Cape Girardeau
- Comfort Suites Jackson-Cape Girardeau
- New cabin in the woods with private hot tub
- Hotel 7 Inn Anna
- Rest, Relax and Renew. Our log cabin experience awaits your arrival.
- Drury Inn & Suites Jackson MO
- Town House Inn
- Wine Country Farmhouse On the Wine 🍷 Trail! Private Lake kayaks Fire Pit 🔥
- Feels like your in a Tree House!On the Wine 🍷Trail! Fire🔥Pit Private Location