This information about transportation options in La Mesa might help your romantic getaway go off without a hitch: To get to La Mesa, you can fly into San Diego, CA (SEE-Gillespie Field), which is the closest major airport, located 4.9 mi (7.8 km) from the city center. Nearby metro stations include La Mesa Boulevard Station, Spring St Trolley Station, and 70th St. Trolley Station.