Find spa resorts & hotels in Over-the-Rhine, Cincinnati from $176

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Top Over-the-Rhine Resorts & Hotels with Spas

21c Museum Hotel Cincinnati

4.5 star property
Downtown Cincinnati
8.6 out of 10, Excellent, (1021)
"Very clean rooms, great bar, friendly staff."
United States
Theodore
$148 nightly
The price is $176
Jan 2 - Jan 3, 2026
Total with taxes and fees
21c Museum Hotel Cincinnati
Lowest nightly price found within the past 24 hours based on a 1 night stay for 2 adults. Prices and availability subject to change. Additional terms may apply.

Find out more about Over-the-Rhine

Top Over-the-Rhine attractions for a relaxing vacation

In the heart of Over-the-Rhine, travelers seeking indulgence will find a blend of relaxation and urban charm. Start your day with a visit to Findlay Market, where you can explore local artisanal foods and fresh produce, perfect for a leisurely brunch before your spa treatments. Afterward, consider a stroll along the historic streets adorned with beautifully restored 19th-century architecture and vibrant murals, showcasing the neighborhood's artistic spirit. For a dose of culture, the Cincinnati Art Museum is just a short drive away, featuring an impressive collection that can inspire tranquility. In the evening, unwind at one of the local breweries, like Rhinegeist, where you can sample craft beers in a lively atmosphere. After a full day, retreat to one of the upscale hotels with spa facilities that Over-the-Rhine offers, such as the 21c Museum Hotel. Here, you can enjoy pampering spa services followed by a restful night in rooms that feature modern amenities and stunning art installations, ensuring you feel rejuvenated and inspired for the adventures that await.

Top Over-the-Rhine Hotel Reviews

Frequently asked questions

Looking for a spa hotel in Over-the-Rhine?
Book one of our lush spa hotels and pamper yourself from the moment you arrive. Check out the live music scene and shopping in Over-the-Rhine—your day trip starts here. Enjoy the art galleries and many popular restaurants during your vacation. Hotels with spas are a great way to break out of your daily routine and add a layer of luxury to your vacation.
What's there to see and do in Over-the-Rhine?
Experience Over-the-Rhine and visit Cincinnati Music Hall, Findlay Market, and Hard Rock Casino Cincinnati. If you have a little extra time during your trip, you might want to make a stop at Rhinegeist Brewery and Ohio River Valley.
What is a Over-the-Rhine spa hotel?
Spa hotels in Over-the-Rhine provide lodging and have a full on-site spa offering services such as massages as well as body treatments. Some also offer in-room treatments. Spa hotels are great for rest, rejuvenation, and relaxation.

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