Find luxury hotels in San Francisco, CA

Some of the most popular luxurious hotels in San Francisco boast indulgent spas and wellness centers. Enjoy a restorative facial, pamper your senses with a therapeutic massage, and rejuvenate body and mind with holistic treatments. Be sure to select the “spa” search filter on Expedia to view these types of properties. Many upscale hotels offer concierge services and curated local experiences, allowing you to uncover San Francisco's hidden gems and get off the beaten path.  

You'll also want to consider the dining options on offer at different San Francisco luxury hotels. The most prestigious properties typically boast opulent restaurants with spectacular views where you can dine on exquisite cuisine. A glass of champagne or after-dinner cocktails are a delightful treat while on vacation, so consider choosing somewhere with an on-site bar. The “bar” and “restaurant” search filters can help locate these. 

Why plan your San Francisco luxury stay on Expedia

From prestigious international brands to high-end local boutiques, you'll find a wide selection of San Francisco luxury hotels on Expedia. The varied search filters give you total control over your search, making it a breeze to find your ideal place to stay. Whether you're seeking a personalized concierge service that caters to your every whim or chic design and elegant interiors, Expedia's detailed hotel descriptions mean you'll know exactly what to expect when you arrive. 

The most upscale stays in San Francisco in 2025 tend to get booked up in advance. Fortunately, many properties on Expedia allow for free cancellation, so might be able to book your first choice of hotel even if your plans aren't 100% certain. Make sure to read the terms and conditions before booking.